A mutation in the voltage-gated sodium channel gene associated with pyrethroid resistance in Latin American Aedes aegypti

Insect Molecular Biology
Karla Saavedra-RodriguezWilliam C Black

Abstract

Pyrethroids are commonly used as mosquito adulticides and evolution of resistance to these compounds is a major threat to public health. 'Knockdown resistance' to pyrethroids (kdr) is frequently caused by nonsynonymous mutations in the voltage-gated sodium channel transmembrane protein (para) that reduce pyrethroid binding. Early detection of kdr is critical to the development of resistance management strategies in mosquitoes including Aedes aegypti, the most prevalent vector of dengue and yellow fever viruses. Brengues et al. described seven novel mutations in hydrophobic segment 6 of domain II of para in Ae. aegypti. Assays on larvae from strains bearing these mutations indicated reduced nerve sensitivity to permethrin inhibition. Two of these occurred in codons Iso1011 and Val1016 in exons 20 and 21 respectively. A transition in the third position of Iso1011 encoded a Met1011 replacement and a transversion in the second position of Val1016 encoded a Gly1016 replacement. We have screened this same region in 1318 mosquitoes in 32 additional strains; 30 from throughout Latin America. While the Gly1016 allele was never detected in Latin America, we found two new mutations in these same codons. A transition in the first position ...Continue Reading

References

Mar 29, 1994·Proceedings of the National Academy of Sciences of the United States of America·T P Monath
Apr 12, 2000·Medical and Veterinary Entomology·M ZaimN Nakashima
Sep 18, 2002·Archives of Medical Research·Duane J Gubler
May 29, 2003·Insect Biochemistry and Molecular Biology·D M Soderlund, D C Knipple
Dec 12, 2003·Bioinformatics·Julio RozasRicardo Rozas
May 17, 2005·Insect Biochemistry and Molecular Biology·Norma Gorrochotegui-EscalanteWilliam C Blackiv
Dec 31, 2005·BioTechniques·Jun WangSoren Germer
Mar 2, 2006·Journal of the American Mosquito Control Association·María Magdalena RodríguezFrancisco Ramos
Feb 20, 2007·Journal of the American Mosquito Control Association·Adriana E FloresBarry J Beaty
May 31, 2008·Advances in Experimental Medicine and Biology·William C BlackMartin J Donnelly
Jun 1, 1968·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·W G Hill, A Robertson

Citations

Mar 1, 2011·Transactions of the Royal Society of Tropical Medicine and Hygiene·Shavanthi RajatilekaHilary Ranson
Jan 9, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jean-Philippe DavidMark Paine
Jan 14, 2011·Parasites & Vectors·Estelita Pereira LimaMaria Alice Varjal de Melo Santos
May 18, 2011·Parasites & Vectors·Basile KamgangChristophe Paupy
Oct 16, 2009·PLoS Neglected Tropical Diseases·Gustavo Ponce GarcíaWilliam C Black Iv
Nov 10, 2011·PLoS Neglected Tropical Diseases·Susana BarbosaIan Hastings
Aug 6, 2010·PloS One·John C MorganCharles Wondji
Feb 15, 2012·Journal of the American Mosquito Control Association·Quetzaly SillerAdriana E Flores
Aug 5, 2010·The American Journal of Tropical Medicine and Hygiene·Angela F HarrisHilary Ranson
Jan 8, 2011·The American Journal of Tropical Medicine and Hygiene·Sébastien MarcombeVincent Corbel
Dec 3, 2014·Pesticide Biochemistry and Physiology·Ronald Maestre-SerranoAdriana E Flores
Feb 1, 2014·Evolution, Medicine, and Public Health·Ademir J MartinsAlexandre Afranio Peixoto
Jun 6, 2009·Journal of Medical Entomology·Julia W PridgeonKenneth J Linthicum
Nov 5, 2013·Journal of Medical Entomology·Leslie C AlvarezAdriana E Flores
Sep 11, 2013·Pesticide Biochemistry and Physiology·Frank D RinkevichKe Dong
Jan 5, 2011·Insect Biochemistry and Molecular Biology·Nongkran LumjuanHilary Ranson
Apr 17, 2009·Trends in Parasitology·Martin J DonnellyWilliam C Black
Aug 27, 2015·Acta Tropica·Hélio Daniel Ribeiro RochaMaria Alice Varjal de Melo Santos
Sep 9, 2009·Tropical Medicine & International Health : TM & IH·Ademir J MartinsDenise Valle
Mar 12, 2011·Pest Management Science·Idalyd Fonseca-GonzálezWilliam Brogdon
Oct 29, 2011·Insect Molecular Biology·Karla Saavedra-RodriguezWilliam C Black
Nov 28, 2012·Journal of Vector Ecology : Journal of the Society for Vector Ecology·Janet McAllisterMariah L Scott
Dec 5, 2013·Insect Molecular Biology·Karla Saavedra-RodriguezWilliam C Black
Oct 16, 2016·Pesticide Biochemistry and Physiology·Letícia B SmithJeffrey G Scott
Aug 5, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Aurélie BoninLaurence Després
May 20, 2015·Pesticide Biochemistry and Physiology·Jeffrey G ScottShinji Kasai
Nov 6, 2012·Insect Biochemistry and Molecular Biology·Theresia Estomih NkyaJean-Philippe David
Feb 9, 2011·Acta Tropica·Clara B OcampoWilliam Brogdon
Mar 23, 2011·Biochemical and Biophysical Research Communications·Qiang XuNannan Liu
Apr 7, 2015·Journal of the American Mosquito Control Association·Steven DenhamKarla Saavedra-Rodriguez
Apr 7, 2015·Journal of the American Mosquito Control Association·Juan Andrés BissetIlario Fuentes
Nov 21, 2015·PLoS Neglected Tropical Diseases·Isabelle DusfourClare Strode
Oct 21, 2014·PLoS Neglected Tropical Diseases·Guadalupe Reyes-SolisWilliam C Black
Aug 6, 2016·Journal of Medical Entomology·Gustavo Ponce-GarciaAdriana E Flores
Feb 17, 2017·Journal of the American Mosquito Control Association·O Karina VillanuevaAdriana E Flores
Oct 31, 2015·Revista Da Sociedade Brasileira De Medicina Tropical·Francesca Guaracyaba Garcia ChapadensePedro Cravo
Jan 30, 2014·Memórias do Instituto Oswaldo Cruz·Gonçalo SeixasCarla A Sousa
Nov 6, 2014·The American Journal of Tropical Medicine and Hygiene·Karla Saavedra-RodriguezWilliam C Black
Jun 5, 2013·The American Journal of Tropical Medicine and Hygiene·Maria A Loroño-PinoBarry J Beaty
Mar 30, 2017·Parasites & Vectors·Oscar Alexander Aguirre-ObandoMário Antônio Navarro-Silva
Jul 21, 2017·PLoS Neglected Tropical Diseases·Catherine MoyesDavid Weetman
Nov 23, 2017·Medical and Veterinary Entomology·Pablo A Kuri-MoralesJesús F González-Roldán
Nov 18, 2017·PLoS Neglected Tropical Diseases·Yanouk EpelboinIsabelle Dusfour
Feb 23, 2019·PloS One·Yashoda KandelImmo A Hansen
Feb 14, 2019·Insect Molecular Biology·Karla Saavedra-RodriguezWilliam C Black
Dec 15, 2015·PLoS Neglected Tropical Diseases·Farah Z Vera-MaloofWilliam C Black Iv
Mar 17, 2020·PLoS Neglected Tropical Diseases·Farah Z Vera-MaloofWilliam C Black
Apr 17, 2020·PLoS Neglected Tropical Diseases·Luciano Veiga CosmeAdemir J Martins
Apr 18, 2020·PLoS Neglected Tropical Diseases·Yinjun FanJeffrey G Scott
May 8, 2020·Archives of Insect Biochemistry and Physiology·Mengli ChenKe Dong
Jan 11, 2019·Parasites & Vectors·Marissa K GrossmanGonzalo M Vazquez-Prokopec
Jan 24, 2019·BioMed Research International·Penny Humaidah HamidCarlos Hermosilla
Jul 28, 2020·PLoS Neglected Tropical Diseases·Sheena FrancisCarolina Torres Gutierrez
Aug 9, 2020·Scientific Reports·Monique Melo CostaAdemir J Martins
Jul 12, 2017·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Maria Laura Gabriel Kuniyoshi, Fernando Luiz Pio Dos Santos
Dec 12, 2017·Journal of Medical Entomology·Pablo A Kuri-MoralesJesús F González-Roldán
Aug 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maíra Rosato Silveiral SilvérioPaulo Cézar Vieira
Jun 27, 2020·Parasites & Vectors·Karina Villanueva-SeguraAdriana E Flores
Jun 13, 2017·PLoS Neglected Tropical Diseases·Gonzalo M Vazquez-ProkopecPablo Manrique-Saide
Jun 10, 2017·Infectious Diseases of Poverty·Leah MathiasEliningaya J Kweka
Oct 11, 2019·PLoS Neglected Tropical Diseases·Isabelle DusfourFabrice Chandre
Dec 16, 2020·Parasites & Vectors·Hasan Mohammad Al-AminAudrey Lenhart

Related Concepts

Aedes
Alleles
Crosses, Genetic
Genetic Equilibrium
Insecticide Resistance
Insecticides
Phylogeny
Pyrethroids
Homologous Sequences, Nucleic Acid
Sodium Channel