A Mycoses Study Group International Prospective Study of Phaeohyphomycosis: An Analysis of 99 Proven/Probable Cases

Open Forum Infectious Diseases
Sanjay G RevankarPeter G Pappas

Abstract

Phaeohyphomycosis is infection caused by dematiaceous, or darkly pigmented, fungi. The spectrum of disease is broad, and optimal therapy remains poorly defined. The Mycoses Study Group established an international case registry of patients with proven/probable phaeohyphomycosis with the goal of improving the recognition and management of these infections. Patients from 18 sites in 3 countries were enrolled from 2009-2015. Cases were categorized as local superficial, local deep (pulmonary, sinus, osteoarticular infections), and disseminated infections. End points were clinical response (partial and complete) and all-cause mortality at 30 days and end of follow-up. Of 99 patients, 32 had local superficial infection, 41 had local deep infection, and 26 had disseminated infection. The most common risk factors were corticosteroids, solid organ transplantation, malignancy, and diabetes. Cultures were positive in 98% of cases. All-cause mortality was 16% at 30 days and 33% at end of follow-up, and 18 of 26 (69%) with dissemination died. Itraconazole was most commonly used for local infections, and voriconazole was used for more severe infections, often in combination with terbinafine or amphotericin B. Phaeohyphomycosis is an increasi...Continue Reading

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Citations

Aug 14, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Minh-Vu H NguyenGeorge R Thompson
Jul 13, 2019·Journal of Fungi·Jon Velasco, Sanjay Revankar
Oct 17, 2019·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Daniela Dalla GasperinaPaolo Antonio Grossi
Aug 18, 2020·The Journal of Infection·Jon Salmanton-GarcíaUNKNOWN ECMM/ISHAM working group
May 29, 2021·Journal of Veterinary Internal Medicine·Sara M Crespo-Szabo, Jennifer R Stafford
Jan 24, 2020·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J D JenksM Hoenigl

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