PMID: 8943895Dec 1, 1996Paper

A myeloproliferative disorder with eosinophilia associated with a unique translocation (3;5)

British Journal of Haematology
A L ShanskeH Grunwald

Abstract

An association between eosinophilia and a structural chromosome abnormality has been noted in patients with acute non-lymphoblastic leukaemia (ANLL) and a deletion of the long arm of chromosome 16. There have been a number of other associations of specific chromosome abnormalities with neoplastic diseases involving the eosinophilic lineage; these include chromosome 12 short arm rearrangements, trisomy 8, t(8;21), t(5;14) and t(5;12). We report a patient with a myeloproliferative disorder characterized by chronic eosinophilic leukaemia complicated by autoimmune haemolytic anaemia and a previously unreported translocation (3;5)(p13;q13), and discuss the possible contribution of the RASA gene, localized to 5q13.3, to the development of the malignant phenotype.

Citations

Apr 16, 2003·British Journal of Haematology·Finella Brito-Babapulle
Jul 9, 2003·British Journal of Haematology·Barbara J Bain
May 10, 2006·British Journal of Haematology·Ayalew TefferiAnimesh Pardanani
Jun 20, 2006·Best Practice & Research. Clinical Haematology·Jason GotlibD Gary Gilliland
Nov 25, 1997·Blood Reviews·F Brito-Babapulle
Jan 22, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Lauren WetzlerPaneez Khoury

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