PMID: 7517631Jun 1, 1994Paper

A Na(+)-sensitive cation channel modulated by angiotensin II in cultured intestinal myocytes

The American Journal of Physiology
V L NouailhetasA C Paiva

Abstract

Single-channel currents were recorded in excised inside-out and cell-attached patches of cultured cells from the longitudinal smooth muscle of the guinea pig ileum. In the presence of symmetrical high-K+ solutions, we identified a voltage-dependent 12-pS channel. It was reversibly blocked by addition of either Ba2+ or Cs+ at the cellular side of the patch but was insensitive to Ca2+ or ATP. This channel had poor selectivity concerning cations (PLi > PK = PNa = PCa, where P is permeability) and low permeability to anions. Isosmotic substitution of NaCl for KCl in the solution facing the cellular side enhanced the channel activity by increasing NPo values where N is number of channels and Po is open probability. In the cell-attached configuration, the channel was also activated by addition of angiotensin II in the bath solution. We propose that this nonselective cation channel might play a role in the control of the membrane potential during the contractile response of the guinea pig ileum to agonists by keeping the voltage-sensitive Ca2+ channels open.

References

Aug 1, 1979·Canadian Journal of Physiology and Pharmacology·C R TriggleD J Triggle
Sep 1, 1987·Pflügers Archiv : European journal of physiology·R InoueH Kuriyama
Feb 1, 1988·Trends in Neurosciences·L D Partridge, D Swandulla
Oct 8, 1985·European Journal of Pharmacology·V L NouailhetasT B Paiva
Sep 22, 1984·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·S BevanJ M Ritchie
Aug 1, 1981·Pflügers Archiv : European journal of physiology·O P HamillF J Sigworth
Aug 1, 1982·Pflügers Archiv : European journal of physiology·S I ShimutaT B Paiva
Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·C FasolatoR Penner
Apr 1, 1993·Naunyn-Schmiedeberg's Archives of Pharmacology·S I ShimutaA C Paiva

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Citations

May 2, 1998·Journal of Neurophysiology·A B ZhainazarovB W Ache
Dec 24, 1998·Journal of Neurophysiology·A B Zhainazarov, B W Ache
May 22, 2002·European Journal of Pharmacology·Jeannine AboulafiaViviane L A Nouailhetas
Jun 1, 2000·Progress in Neurobiology·T MiyamotoT Sato

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