A Nanobody-Conjugated DNA Nanoplatform for Targeted Platinum-Drug Delivery

Angewandte Chemie
Tiantian WuBaoquan Ding

Abstract

The targeted delivery of chemotherapeutic drugs is a major challenge in the clinical treatment of cancer. Herein, we constructed a multifunctional DNA nanoplatform as a versatile carrier of the highly potent platinum-based DNA intercalator, 56MESS. In our rational design, 56MESS was efficiently loaded into the double-bundle DNA tetrahedron through intercalation with the DNA duplex. With the integration of a nanobody that both targets and blocks epidermal growth factor receptor (EGFR), the DNA nanocarriers exhibit excellent selectivity for cells with elevated EGFR expression (a common biomarker related to tumor formation) and combined tumor therapy without obvious systemic toxicity. This DNA-based platinum-drug delivery system provides a promising strategy for the treatment of tumors.

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Citations

Mar 14, 2020·Chemistry : a European Journal·Manman LiuYangzhong Liu
May 5, 2020·Nanoscale Horizons : the Home for Rapid Reports of Exceptional Significance in Nanoscience and Nanotechnolgy·Fang DingHaihua Xiao
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Aug 31, 2020·Advanced Healthcare Materials·Xiaohui WuBaoquan Ding
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Dec 19, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Weijia LuYi Qi
Feb 10, 2021·ACS Applied Materials & Interfaces·Manman HeXia Chu
Dec 12, 2020·Advanced Science·Fay NicolsonSuchetan Pal
Mar 1, 2020·Drug Discovery Today·Yunfeng LinLei Zhang
Apr 2, 2021·International Journal of Nanomedicine·Shuyang SunXiaoling Lu
Apr 29, 2021·ACS Applied Materials & Interfaces·Wantao TangBaoquan Ding
Apr 20, 2021·Bioinorganic Chemistry and Applications·Xueqin HuangJiang Pi
May 9, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sandeep Surendra PanikarPedro Salas
May 22, 2021·Advanced Healthcare Materials·Shilin LiYing Liu
Jul 3, 2020·ACS Applied Materials & Interfaces·Tiantian WuBaoquan Ding
Dec 1, 2020·ACS Applied Materials & Interfaces·Daxiu LiYun Xiang
Sep 1, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Yunhua GuoDayong Yang
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