A Nanoplatform with Precise Control over Release of Cargo for Enhanced Cancer Therapy

Small
Qianqian QuShaobing Zhou

Abstract

The development of a nanocarrier delivery system having both sufficient stability in blood circulation and a rapid drug release profile at target sites remains a major challenge in cancer therapy. Here, a multifunctional star-shaped micellar system with a precisely spatiotemporal control of releasing encapsulated agents is developed by mixing a photoinitiated crosslinking amphiphilic copolymer with a phenylboronic acid (PBA)-functionalized redox-sensitive amphiphilic copolymer for the first time. The combination of the functional polymers effectively resolves the contradiction that the micellar system cannot release the rapid drug release in cells when it possesses an extreme stability that is often required in blood circulation. In this system, the inner core polymers are photo-crosslinked, endowing a stable micelle matrix structure; the end groups of the hydrophilic segments are decorated with PBA ligands, providing an active targeting ability; disulfide bonds in the micellar matrix impart a redox-responsive trigger for the prompt intracellular release of drugs. As a result, with a relatively low DOX dosage (2 mg kg(-1) per injection) the in vivo antitumor effect on H22-bearing BALB/c mice shows that the micelles have a high ...Continue Reading

References

Mar 2, 2005·Nature Reviews. Cancer·Mauro Ferrari
Jul 12, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Abdel-Kareem AzabAbraham Rubinstein
Nov 18, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Geneviève GaucherJean-Christophe Leroux
Dec 1, 2005·Journal of the American Chemical Society·Maisie J JoralemonKaren L Wooley
Jul 26, 2008·Nature Nanotechnology·Dan PeerRobert Langer
Nov 4, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Vladimir Torchilin
Feb 12, 2009·ACS Nano·Omid C Farokhzad, Robert Langer
Dec 8, 2009·Journal of Pharmaceutical Sciences·Alyssa M MasterAnirban Sen Gupta
Jun 15, 2010·Nanomedicine : Nanotechnology, Biology, and Medicine·Uttam KedarVilasrao Kadam
Sep 8, 2010·Chemical Society Reviews·Ewan Galbraith, Tony D James
Feb 8, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ru ChengZhiyuan Zhong
Mar 25, 2011·Advanced Materials·José A BarretoLeone Spiccia
Apr 5, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·S CajotC Jérôme
Aug 13, 2011·Small·Nicolas MackiewiczFrédéric Ducongé
Sep 20, 2011·Bioconjugate Chemistry·Emmanuelle MorinJean-Serge Remy
Jan 17, 2012·Accounts of Chemical Research·Chao WangXi Zhang
Feb 15, 2012·Advanced Drug Delivery Reviews·Min Suk Shim, Young Jik Kwon
Apr 25, 2012·Journal of the American Chemical Society·Kejin ZhouJinming Gao
Jan 1, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Esmaiel JabbariXuezhong He
Jan 31, 2013·Nanoscale·Edmond GravelEric Doris
Mar 28, 2013·ACS Applied Materials & Interfaces·Jun ChenMalcolm Mq Xing
Sep 14, 2013·Journal of the American Chemical Society·Stephanie DeshayesKazunori Kataoka
Sep 26, 2013·Advanced Drug Delivery Reviews·Yuanpei LiKit S Lam
Oct 24, 2013·Nature Materials·Simona MuraPatrick Couvreur
Jan 7, 2014·Biomaterials·Jie WangShaobing Zhou
Feb 13, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Wei YangShaoyi Jiang
May 24, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yan ZouZhiyuan Zhong

❮ Previous
Next ❯

Citations

Aug 12, 2016·The Journal of Physical Chemistry. B·Wenjuan JiangShikha Nangia
Jan 11, 2017·ACS Applied Materials & Interfaces·Lei ZhangShaobing Zhou
Sep 4, 2018·Journal of Drug Targeting·Li LiDong-Gang Xu
Jul 30, 2019·Advanced Materials·Peng MiKazunori Kataoka
Apr 1, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Lu LuKaiyong Cai
Jan 7, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Pu WangShaobing Zhou
Dec 13, 2016·Advanced Healthcare Materials·Zhaomin TangShaobing Zhou
Dec 8, 2020·Frontiers in Chemistry·Qiong HuangJianhua Liu
Aug 30, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Wenwu XiaoYuanpei Li
Jun 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Nidhi RavalRakesh K Tekade
May 21, 2020·Current Drug Metabolism·Abu BakerMohd Sajid Khan
Dec 17, 2021·Journal of Biomedical Materials Research. Part a·Yuxuan MaYong Yao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.