A Nanowatt Real-Time Cardiac Autonomic Neuropathy Detector

IEEE Transactions on Biomedical Circuits and Systems
Temesghen TekesteMohammed Ismail

Abstract

This paper presents an electrocardiogram (ECG) processor on chip for full ECG feature extraction and cardiac autonomic neuropathy (CAN) classification. Full ECG extraction is performed using absolute value curve length transform (A-CLT) for $\text{QRS}_{\text{peak}}$ detection and using low-pass differentiation for other ECG features such as $\text{QRS}_{\text{on}}$, $\text{QRS}_{\text{off}}$, Pwave, and Twave. The proposed QRS detector attained a sensitivity of 99.37% and predictivity of 99.38%. The extracted $\text{QRS}_{\text{peak}}$ to $\text{QRS}_{\text{peak}}$ intervals (RR intervals) along with QT intervals enable CAN severity detection, which is a cardiac arrhythmia usually seen in diabetic patients leading to increased risk of sudden cardiac death. This paper presents the first hardware real-time implementation of CAN severity detector that is based on RR variability and QT variability analysis. RR variability metrics are based on mean RR interval and root mean square of standard differences of the RR intervals. The proposed architecture was implemented in 65-nm technology and consumed 75 nW only at 0.6 V, when operating at 250 Hz. Ultralow power dissipation of the system enables it to be integrated into wearable healt...Continue Reading

References

May 1, 1992·Diabetologia·M D RollinsS Z Imam
Oct 2, 1982·British Medical Journal·D J Ewing, B F Clarke
Sep 1, 1997·Diabetes·V Spallone, G Menzinger
Apr 10, 2004·IEEE Transactions on Bio-medical Engineering·Juan Pablo MartínezPablo Laguna
Aug 30, 2012·IEEE Transactions on Information Technology in Biomedicine : a Publication of the IEEE Engineering in Medicine and Biology Society·Ahsan H KhandokerHerbert F Jelinek
Jan 31, 2013·IEEE Journal of Biomedical and Health Informatics·Evangelos B MazomenosNick Curzen
Jul 16, 2013·IEEE Transactions on Biomedical Circuits and Systems·Chio-In IeongRui P Martins
Jul 31, 2013·IEEE Transactions on Biomedical Circuits and Systems·Young-Jae MinSoo-Won Kim
Oct 28, 2014·IEEE Journal of Biomedical and Health Informatics·Jemal AbawajyHerbert Jelinek
Jan 7, 2015·IEEE Journal of Biomedical and Health Informatics·Shuenn-Yuh LeeKuang-Hao Lin
Jan 9, 2015·Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society·Mika P TarvainenHerbert F Jelinek
Feb 22, 2017·IEEE Journal of Biomedical and Health Informatics·Jose Manuel BoteRoman Hermida
Sep 4, 2017·IEEE Transactions on Biomedical Circuits and Systems·Peng LiHongda Chen

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Citations

Jun 24, 2020·Journal of the Royal Society, Interface·Jeffrey J KimJames N Kirby

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