A Narrative Review of Placental Contribution to Adverse Pregnancy Outcomes in Women With Polycystic Ovary Syndrome

The Journal of Clinical Endocrinology and Metabolism
Angela S KelleyVasantha Padmanabhan

Abstract

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy of reproductive-aged women. In pregnancy, women with PCOS experience increased risk of miscarriage, gestational diabetes, preeclampsia, and extremes of fetal birth weight, and their offspring are predisposed to reproductive and cardiometabolic dysfunction in adulthood. Pregnancy complications, adverse fetal outcomes, and developmental programming of long-term health risks are known to have placental origins. These findings highlight the plausibility of placental compromise in pregnancies of women with PCOS. A comprehensive PubMed search was performed using terms "polycystic ovary syndrome," "placenta," "developmental programming," "hyperandrogenism," "androgen excess," "insulin resistance," "hyperinsulinemia," "pregnancy," and "pregnancy complications" in both human and animal experimental models. There is limited human placental research specific to pregnancy of women with PCOS. Gestational androgen excess and insulin resistance are two clinical hallmarks of PCOS that may contribute to placental dysfunction and underlie the higher rates of maternal-fetal complications observed in pregnancies of women with PCOS. Additional research is needed to prevent adverse m...Continue Reading

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Citations

Dec 5, 2020·Fertility and Sterility·Sonia L Robinson, Edwina H Yeung
Feb 18, 2021·Nature Communications·Camille BourgneufChrystèle Racine
Jan 8, 2021·BMC Pregnancy and Childbirth·Jing LiQing Liu
Feb 2, 2021·Endocrinology and Metabolism Clinics of North America·Amy M Valent, Linda A Barbour
Jun 18, 2021·Journal of Assisted Reproduction and Genetics·Maya RamAnat Lavie
Aug 28, 2020·Protein and Peptide Letters·Virginia M PereiraAdelina M Reis
Dec 2, 2021·The Journal of Clinical Endocrinology and Metabolism·Yuexin GanJian Zhao

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