A nationwide database study on colectomy and colorectal cancer in ulcerative colitis: what is the role of appendectomy?

Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Merel E StellingwerfParelsnoer Institute, the Dutch Initiative on Crohn, Colitis*a

Abstract

Although has been suggested that an appendectomy has a positive effect on the disease course in patients with ulcerative colitis (UC), recent studies indicate a potential increase in risk of colectomy and colorectal cancer (CRC). This study aimed to evaluate the rates of colectomy and CRC after appendectomy in UC patients using a nationwide prospective database [the Initiative on Crohn and Colitis Parelsnoer Institute - Inflammatory Bowel Disease (ICC PSI-IBD) database]. All UC patients were retrieved from the ICC PSI-IBD database between January 2007 and May 2018. Primary outcomes were colectomy and CRC. Outcomes were compared in patients with and without appendectomy, with a separate analysis for timing of appendectomy (before or after UC diagnosis). A total of 826 UC patients (54.7% female; median age 46 years, range 18-89 years) were included. Sixty-three (7.6%) patients had previously undergone appendectomy: 24 (38.1%) before and 33 (52.4%) after their diagnosis of UC. In multivariate analysis, appendectomy after UC diagnosis was associated with a significantly lower colectomy rate compared with no appendectomy [hazard ratio (HR) 0.16, 95% C: 0.04-0.66, P = 0.011], and the same nonsignificant trend was seen in patients wit...Continue Reading

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Citations

Jan 28, 2021·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·J DaviesS R Brown

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