A nationwide pathology study on surgical margins and excision volumes after breast-conserving surgery: There is still much to be gained

The Breast : Official Journal of the European Society of Mastology
M H HalouaM Petrousjka van den Tol

Abstract

The current study aims to assess margin status in relation to amount of healthy breast tissue resected in breast-conserving surgery (BCS) on a nationwide scale. Using PALGA (a nationwide network and registry of histology and cytopathology in the Netherlands), all patients who underwent BCS for primary invasive carcinoma in 2012-13 were selected (10,058 excerpts). 9276 pathology excerpts were analyzed for a range of criteria including oncological margin status and distance to closest margin, specimen weight/volume, greatest tumor diameter, and with or without localization method. Calculated resection ratios (CRR) were assessed to determine excess healthy breast tissue resection. Margins for invasive carcinoma and in situ carcinoma combined were tumor-involved in 498 (5.4%) and focally involved in 1021 cases (11.0%) of cases. Unsatisfactory resections including (focally) involved margins and margins ≤ 1 mm were reported in 33.8% of patients. The median lumpectomy volume was 46 cc (range 1-807 cc; SD 49.18) and median CRR 2.32 (range 0.10-104.17; SD 3.23), indicating the excision of 2.3 the optimal resection volume. The unacceptable rate of tumor-involved margins as well as margins ≤ 1 mm in one third of all patients is also achie...Continue Reading

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Citations

Jan 26, 2017·Chemical Communications : Chem Comm·Yi WangMarcel P Bruchez
Dec 8, 2017·Breast Cancer Research and Treatment·José H VoldersM Petrousjka van den Tol
Jun 12, 2020·Annals of Surgical Oncology·Francesca Tamburelli, Riccardo Ponzone
Jul 22, 2018·The British Journal of Radiology·Eoghan ShanleyMichael Sugrue
May 24, 2021·Breast Cancer Research : BCR·Lisanne L de BoerTheo J M Ruers
May 16, 2021·The Breast : Official Journal of the European Society of Mastology·Francesco GarzottoTania Saibene

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