A nationwide, retrospective, data-linkage, cohort study of epilepsy and incident dementia.

Neurology
Christian SchnierRichard F M Chin

Abstract

To determine the association of epilepsy with incident dementia by conducting a nationwide, retrospective data-linkage, cohort study to examine whether the association varies according to dementia subtypes and to investigate whether risk factors modify the association. We used linked health data from hospitalization, mortality records, and primary care consultations to follow up 563,151 Welsh residents from their 60th birthday to estimate dementia rate and associated risk factors. Dementia, epilepsy, and covariates (medication, smoking, comorbid conditions) were classified with the use of previously validated code lists. We studied rate of dementia and dementia subtypes in people with epilepsy (PWE) and without epilepsy using (stratified) Kaplan-Meier plots and flexible parametric survival models. PWE had a 2.5 (95% confidence interval [CI] 2.3-2.6) times higher hazard of incident dementia, a 1.6 (95% CI 1.4-1.8) times higher hazard of incident Alzheimer disease (AD), and a 3.1 (95% CI 2.8-3.4) times higher hazard of incident Vascular dementia (VaD). A history of stroke modified the increased incidence in PWE. PWE who were first diagnosed at ≤25 years of age had a dementia rate similar to that of those diagnosed later in life. ...Continue Reading

References

May 31, 2006·Dementia and Geriatric Cognitive Disorders·D A Lozsadi, A J Larner
Jan 20, 2009·BMC Medical Informatics and Decision Making·Ronan A LyonsKen Leake
Feb 12, 2009·Journal of the American Geriatrics Society·Mary Jo V PughAnne C Van Cott
Sep 4, 2012·Handbook of Clinical Neurology·Christoph Helmstaedter, Juri-Alexander Witt
Jul 10, 2013·JAMA Neurology·Keith A VosselLennart Mucke
Mar 25, 2015·Seizure : the Journal of the British Epilepsy Association·Juri-Alexander Witt, Christoph Helmstaedter
Apr 16, 2015·Epilepsia·William O PickrellMike P Kerr
Jul 25, 2017·Lancet·Gill LivingstonNaaheed Mukadam
Oct 24, 2017·Seizure : the Journal of the British Epilepsy Association·Beata Fonferko-ShadrachW Owen Pickrell
Mar 23, 2018·Journal of the American Geriatrics Society·Heidi TaipaleBritta Haenisch
Mar 29, 2018·Journal of Neurology, Neurosurgery, and Psychiatry·Arron S LaceyMark I Rees
Apr 6, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Tim WilkinsonUNKNOWN UK Biobank Neurodegenerative Outcomes Group and Dementias Platform UK
Feb 27, 2019·European Journal of Epidemiology·Tim WilkinsonUNKNOWN Dementias Platform UK and UK Biobank
Jun 25, 2019·JAMA Internal Medicine·Carol A C CouplandJulia Hippisley-Cox

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