A Nationwide Screen of Carbapenem-Resistant Klebsiella pneumoniae Reveals an Isolate with Enhanced Virulence and Clinically Undetected Colistin Heteroresistance

Antimicrobial Agents and Chemotherapy
Jessie E WozniakDavid S Weiss

Abstract

The convergence of hypervirulence and multidrug resistance in Klebsiella pneumoniae is a significant concern. Here, we report the first screen for hypermucoviscosity, a trait associated with increased virulence, using a U.S. surveillance collection of carbapenem-resistant (CR) K. pneumoniae isolates. We identified one hypermucoviscous isolate, which carried a gene encoding the KPC-3 carbapenemase, among numerous resistance genes. The strain further exhibited colistin heteroresistance undetected by diagnostics. This convergence of diverse resistance mechanisms and increased virulence underscores the need for enhanced K. pneumoniae surveillance.

References

Oct 9, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Wei LiHao Wu
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Oct 11, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M CuberoC Ardanuy
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Nov 6, 2017·The Lancet Infectious Diseases·Pengcheng DuChen Chen

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Citations

Nov 5, 2019·Journal of Internal Medicine·J E ChobyD S Weiss
Apr 27, 2021·Frontiers in Cellular and Infection Microbiology·Dakang HuXiaofei Jiang

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