PMID: 9432980Feb 7, 1998Paper

A natural immunological adjuvant enhances T cell clonal expansion through a CD28-dependent, interleukin (IL)-2-independent mechanism

The Journal of Experimental Medicine
A KhorutsMarc K Jenkins

Abstract

The adoptive transfer of naive CD4(+) T cell receptor (TCR) transgenic T cells was used to investigate the mechanisms by which the adjuvant lipopolysaccharide (LPS) enhance T cell clonal expansion in vivo. Subcutaneous administration of soluble antigen (Ag) resulted in rapid and transient accumulation of the Ag-specific T cells in the draining lymph nodes (LNs), which was preceded by the production of interleukin (IL)-2. CD28-deficient, Ag-specific T cells produced only small amounts of IL-2 in response to soluble Ag and did not accumulate in the LN to the same extent as wild-type T cells. Injection of Ag and LPS, a natural immunological adjuvant, enhanced IL-2 production and LN accumulation of wild-type, Ag-specific T cells but had no significant effect on CD28-deficient, Ag-specific T cells. Therefore, CD28 is critical for Ag-driven IL-2 production and T cell proliferation in vivo, and is essential for the LPS-mediated enhancement of these events. However, enhancement of IL-2 production could not explain the LPS-dependent increase of T cell accumulation because IL-2-deficient, Ag-specific T cells accumulated to a greater extent in the LN than wild-type T cells in response to Ag plus LPS. These results indicate that adjuvants ...Continue Reading

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Citations

Jun 20, 2002·Veterinary Immunology and Immunopathology·Michael P Murtaugh, Dennis L Foss
Feb 15, 2003·Veterinary Immunology and Immunopathology·Dennis L FossMichael P Murtaugh
Nov 15, 2001·Animal Health Research Reviews·D L Foss, M P Murtaugh
Sep 17, 2008·Immunology and Cell Biology·Esma S YolcuShai Yarkoni
Dec 8, 1998·The Journal of Experimental Medicine·B PulendranC R Maliszewski
Nov 9, 2000·The Journal of Experimental Medicine·J F PanusM G McHeyzer-Williams
Feb 22, 2007·The Journal of Experimental Medicine·Hans DoomsAbul K Abbas
Jan 23, 2003·Annals of the New York Academy of Sciences·Thomas C MitchellPhilippa Marrack
Jun 23, 2006·Infection and Immunity·Paula M Chilton, Thomas C Mitchell
Mar 13, 2001·Annual Review of Immunology·M K JenkinsK A Pape
Mar 23, 2006·Annual Review of Immunology·Nicolas BidèreMichael J Lenardo
Dec 8, 2007·Annual Review of Immunology·Thomas R Malek
Oct 5, 2010·The Journal of Clinical Investigation·Ingunn M StromnesPhilip D Greenberg
Jan 27, 2009·Critical Reviews in Immunology·Jeremy P McAleer, Anthony T Vella
May 21, 2005·Drugs & Aging·Johan W de Fijter
Jun 21, 2001·Cellular Immunology·A R WeatherillA T Vella
Oct 29, 2013·In Vitro Cellular & Developmental Biology. Animal·Yoshiaki AndoManabu Inobe
Mar 19, 2014·Veterinary Immunology and Immunopathology·Michael P Murtaugh
Feb 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·B PulendranC R Maliszewski
Feb 13, 2014·Proceedings of the National Academy of Sciences of the United States of America·John A AltinChristopher C Goodnow
Sep 30, 2015·Proceedings of the National Academy of Sciences of the United States of America·Jonathan L LinehanMarc K Jenkins
Sep 24, 2004·European Journal of Immunology·Warren N D'Souza, Leo Lefrançois
Mar 27, 2007·Seminars in Immunology·Anna Mondino, Daniel L Mueller
Jun 23, 2007·Transplant Immunology·Shuang WangCaigan Du

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