A natural killer T-cell subset that protects against airway hyperreactivity

The Journal of Allergy and Clinical Immunology
Ya-Ting ChuangD T Umetsu

Abstract

Infection of suckling mice with influenza virus expands a CD4-CD8- double-negative (DN) natural killer T (NKT) cell subpopulation that protects the mice as adults against allergen-induced airway hyperreactivity (AHR). However, this NKT cell subset has not been characterized, and the underlying mechanisms of protection remain unknown. We characterized this specific NKT cell subpopulation that developed during influenza infection in neonatal mice and that suppressed the subsequent development of AHR. A cell-surface marker was identified by comparing the mRNA expression profile of wild-type CD4+ NKT cells with that of suppressive Vα14 DN NKT cells. The marker-enriched NKT cell subset was then analyzed for its cytokine profile and its suppressive in vitro and in vivo abilities. We showed that DN NKT cells with high CD38 expression produced IFN-γ, but not IL-17, IL-4, or IL-13, and inhibited development of AHR through contact-dependent suppression of helper CD4 T-cell proliferation. The NKT subset expanded in the lungs of neonatal mice after infection with influenza and also after treatment of neonatal mice with Nu-α-GalCer, which effectively increased DN CD38hi NKT cell numbers. These results suggest that early/neonatal exposure to...Continue Reading

Citations

Jul 2, 2020·American Journal of Respiratory Cell and Molecular Biology·Andrew D PriggeKaren M Ridge
Sep 17, 2020·Allergy, Asthma & Immunology Research·Xinliu LinJing Li
Mar 18, 2020·Allergy·Marcela de Lima MoreiraSidonia B G Eckle
Sep 3, 2019·The Journal of Allergy and Clinical Immunology·Leonard B BacharierHirohito Kita
Aug 9, 2021·Molecular Aspects of Medicine·Zsolt I KomlósiCezmi A Akdis
Oct 17, 2021·The Journal of Allergy and Clinical Immunology·Rachel L MillerKasey Strothman

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