A near-infrared two-photon-sensitive peptide-mediated liposomal delivery system

Colloids and Surfaces. B, Biointerfaces
Yang YangXingGuo Mei

Abstract

Tumour-oriented nanocarrier drug delivery approaches with photo-sensitivity have been drawing considerable attention over the years. However, due to its low penetrability and ability to induce tissue damage, the use of UV light for triggered nanocarrier release in in vivo applications has been limited. Compared with UV light, near-infrared (NIR) light deeply penetrates tissues and is less damaging to cells. Here, we report on the development of a novel method employing photo-sensitive cell-penetrating peptides (CPPs), which can be used to trigger the transport of liposomes into cells following stimulation, which was irradiation with NIR light in this case. The positive charges of the lysine residues on the CPP were temporarily caged by a NIR two-photon excitation-responsive protective group (PG), thereby forming photo-sensitive peptides (PSPs). The PSP was connected with DSPE via a polyethylene glycol (PEG) spacer to prepare the modified liposomes (PSP-L). Once illuminated by NIR light in tumour tissues, these PGs were cleaved, and the positively charged CPP regained its activity and facilitated rapid intracellular delivery of the liposomes into cancer cells. The PSP-L carrying vinorelbine bitartrate prepared in this work posse...Continue Reading

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Citations

Dec 5, 2015·Expert Opinion on Drug Delivery·Kaido KurrikoffÜlo Langel
Feb 11, 2016·International Journal of Pharmaceutics·Yingshu FengXiming Xu
May 18, 2016·Nanomedicine : Nanotechnology, Biology, and Medicine·Bin DuJie Zhou
Aug 20, 2016·Advanced Drug Delivery Reviews·Huihui KuangEfrosini Kokkoli
May 19, 2017·Angewandte Chemie·Nicholas AnkenbruckAlexander Deiters
Feb 16, 2019·Current Medicinal Chemistry·Xinyu HeZiyang Cao

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