A Needle-Type Microrobot for Targeted Drug Delivery by Affixing to a Microtissue

Advanced Healthcare Materials
Seungmin LeeHongsoo Choi

Abstract

A needle-type microrobot (MR) for targeted drug delivery is developed to stably deliver drugs to a target microtissue (MT) for a given period time without the need for an external force after affixing. The MRs are fabricatedby 3D laser lithography and nickel (Ni)/titanium oxide (TiO2 ) layers are coated by physical vapor deposition. The translational velocity of the MR is 714 µm s-1 at 20 mT and affixed to the target MT under the control of a rotating magnetic field. The manipulability of the MR is shown by using both manual and automatic controls. Finally, drug release from the paclitaxel-loaded MR is characterized to determine the efficiency of targeted drug delivery. This study demonstrates the utility of the proposed needle-type MR for targeted drug delivery to MT with various flow rates in vitro physiological fluidic environments.

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Citations

Dec 3, 2020·Micromachines·Ada-Ioana Bunea, Rafael Taboryski
Dec 18, 2020·Advanced Healthcare Materials·Junhee ChoiHongsoo Choi
Dec 11, 2020·Materials Today. Bio·M KoleosoX Chen
Apr 1, 2021·Chemical Reviews·Huaijuan ZhouMartin Pumera
Apr 10, 2021·Multifunctional Materials·Shuai WuRuike Zhao
Aug 4, 2021·Journal of the American Chemical Society·Gerardo SalinasAlexander Kuhn
Jul 15, 2020·Chemical Reviews·Mihyun LeeMarcy Zenobi-Wong

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