A negative loop within the nuclear pore complex controls global chromatin organization

Genes & Development
Manuel Breuer, Hiroyuki Ohkura

Abstract

The nuclear pore complex (NPC) tethers chromatin to create an environment for gene regulation, but little is known about how this activity is regulated to avoid excessive tethering of the genome. Here we propose a negative regulatory loop within the NPC controlling the chromatin attachment state, in which Nup155 and Nup93 recruit Nup62 to suppress chromatin tethering by Nup155. Depletion of Nup62 severely disrupts chromatin distribution in the nuclei of female germlines and somatic cells, which can be reversed by codepleting Nup155. Thus, this universal regulatory system within the NPC is crucial to control large-scale chromatin organization in the nucleus.

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Citations

Feb 13, 2016·Frontiers in Cell and Developmental Biology·Haruhiko AsakawaTokuko Haraguchi
Mar 11, 2016·Nucleus·Richik N MukherjeeDaniel L Levy
Apr 17, 2016·Current Opinion in Cell Biology·Christopher Ptak, Richard W Wozniak
May 18, 2016·Trends in Genetics : TIG·Rakefet Ben-YishayYaron Shav-Tal
Sep 9, 2017·The Journal of Cell Biology·Diego L LapetinaRichard W Wozniak
Nov 3, 2017·Nucleus·Maximiliano A D'Angelo
Nov 5, 2019·PloS One·Eralda SalatajCharalampos G Spilianakis
Jun 14, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Maria Girbes MinguezRalf Kleene
Dec 17, 2016·Epigenetics & Chromatin·Ajay S LabadeKundan Sengupta
Sep 9, 2020·Journal of Receptor and Signal Transduction Research·Xiao-Ying JiangLan Xi
Jan 1, 2021·The Journal of Cell Biology·Pedro BarbosaHiroyuki Ohkura
Feb 11, 2021·Trends in Biochemical Sciences·Javier Fernandez-Martinez, Michael P Rout

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