A nematode allergen elicits protection against challenge infection under specific conditions

Vaccine
Susanne HartmannRichard Lucius

Abstract

We describe tropomyosin of the filarial nematode Acanthocheilonema viteae as an allergen and study its protective potential in the natural rodent host Meriones unguiculatus (jird). Jirds immunized with recombinant E. coli-expressed A. viteae tropomyosin emulsified in alum were not protected, while immunization with recombinant A. viteae tropomyosin or with protein purified from worms together with the adjuvant STP led to reduction of adult worm burdens by 30%. Vaccination with cDNA induced protection of about 30%, while application of cDNA together with aluminium phosphate increased the protection to >40%. Our data suggest that vaccination with tropomyosin under Th1 conditions, which are atypical for nematode infections, induces protection via an antibody independent effector mechanism.

Citations

Mar 24, 2011·Future Medicinal Chemistry·Prashant Kumar SinghShailja Misra-Bhattacharya
Jul 5, 2013·Clinical Microbiology Reviews·C Paul MorrisEdward Mitre
Aug 18, 2012·Parasites & Vectors·Runhui ZhangGuangyou Yang
Oct 17, 2008·Journal of Helminthology·N N MandalM K Beuria
May 3, 2008·Trends in Parasitology·Michal J SeredaRichard Lucius
Oct 20, 2007·Trends in Parasitology·Peter GeldhofEdwin Claerebout
Jul 9, 2008·Molecular and Biochemical Parasitology·Matthias LendnerSusanne Hartmann
Sep 9, 2016·Parasites & Vectors·Bronwyn CampbellDomenico Otranto
Dec 28, 2010·The Journal of Allergy and Clinical Immunology·Helton C SantiagoThomas B Nutman

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