A Neoadjuvant Chemotherapy Trial for Early Breast Cancer is Impacted by COVID-19: Addressing Vaccination and Cancer Trials Through Education, Equity, and Outcomes.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
David A PotterHope S Rugo

Abstract

While COVID-19 vaccine distribution has addressed vulnerabilities related to age and comorbidities, there is a need to ensure vaccination of patients with cancer receiving experimental and routine treatment, where interruption of treatment by infection is likely to result in inferior outcomes. Among patients with cancer, those undergoing neoadjuvant chemotherapy (NAC) or adjuvant chemotherapy (Adj chemo) for early breast cancer (EBC) are at particularly high risk for inferior outcomes, in part, because optimal timing of chemotherapy is essential for promoting distant disease-free survival. COVID-19 data from the ongoing multicenter I-SPY 2 trial of NAC for EBC provides a window into the magnitude of the problem of treatment interruption, not only for the trial itself but also for routine Adj chemo. In the I-SPY 2 trial, 4.5% of patients had disruption of therapy by COVID-19, prior to wide vaccine availability, suggesting that nationally up to 5,700 patients with EBC were at risk for adverse outcomes from COVID-19 infection in 2020. To address this problem, vaccine education and public engagement are essential to overcome hesitancy, while equity of distribution is needed to address access. To accomplish these goals, healthcare o...Continue Reading

References

Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H JoensuuL M Parvinen
Jun 26, 1999·Lancet·R PatelI Reid
Mar 27, 2001·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·M MontellaP Silvestra
Feb 3, 2005·Annals of Internal Medicine·Marc L Citron
Oct 28, 2005·The New England Journal of Medicine·Donald A BerryUNKNOWN Cancer Intervention and Surveillance Modeling Network (CISNET) Collaborators
Jul 28, 2006·Cancer Nursing·JoAnne Ziegler, Marc Citron
May 15, 2009·Clinical Pharmacology and Therapeutics·A D BarkerL J Esserman
Jan 1, 2008·Breast Care·Michael UntchGünter Steger
Feb 26, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Angela DeMicheleLaura J Esserman
Jul 15, 2016·The New England Journal of Medicine·John W ParkUNKNOWN I-SPY 2 Investigators
Jul 15, 2016·The New England Journal of Medicine·Hope S RugoUNKNOWN I-SPY 2 Investigators
Jun 2, 2018·Science·Katharine Hayhoe
Jun 5, 2018·The New England Journal of Medicine·Joseph A SparanoGeorge W Sledge
Sep 25, 2019·Nature Reviews. Disease Primers·Nadia HarbeckFatima Cardoso
Jul 2, 2020·The New England Journal of Medicine·Laura M SpringBeverly Moy
Jul 28, 2020·Journal of the American College of Radiology : JACR·Alexander M NorbashDieter Enzmann
Sep 13, 2020·Journal of Community Health·Farha Musharrat Noor, Md Momin Islam
Nov 24, 2020·Radiologic Clinics of North America·Phoebe E Freer
Dec 24, 2020·Cancer Discovery·Antoni RibasUNKNOWN AACR COVID-19 and Cancer Task Force
Dec 31, 2020·Journal of Molecular Cell Biology·Hui YangFajian Hou
Jan 27, 2021·Cell·Alessandro Sette, Shane Crotty
Jan 28, 2021·The New England Journal of Medicine·Thomas H Lee, Alice H Chen
Jan 31, 2021·Journal of Medical Ethics·Lori Bruce, Ruth Tallman
Feb 6, 2021·AJR. American Journal of Roentgenology·Christine E EdmondsEmily F Conant
Feb 12, 2021·The Lancet Oncology·Timothy A YapUdai Banerji
Mar 4, 2021·PloS One·Federico Germani, Nikola Biller-Andorno
Mar 5, 2021·Faculty Reviews·David A PotterDouglas Yee
Mar 16, 2021·JAMA : the Journal of the American Medical Association·Rachel Wilf-MironMor Saban
Mar 17, 2021·Nature Reviews. Clinical Oncology·Aakash DesaiUNKNOWN COVID19 and Cancer Clinical Trials Working Group
Apr 4, 2021·Journal of Medical Ethics·Nancy S Jecker

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