A neonatal sequential organ failure assessment score predicts mortality to late-onset sepsis in preterm very low birth weight infants.

Pediatric Research
James L Wynn, Richard A Polin

Abstract

An operational definition of organ dysfunction applicable to neonates that predicts mortality in the setting of infection is lacking. We determined the utility of an objective, electronic health record (EHR)-automated, neonatal sequential organ failure assessment (nSOFA) score to predict mortality from late-onset sepsis (LOS) in premature, very low birth weight (VLBW) infants. Retrospective, single-center study of bacteremic preterm VLBW newborns admitted between 2012 and 2016. nSOFA scores were derived for patients with LOS at multiple time points surrounding the sepsis evaluation. nSOFA scores at evaluation and at all points measured after evaluation were different between survivors and non-survivors. Among patients with an nSOFA score of >4, mortality was higher at evaluation (13% vs 67%, p < 0.001), +6 h (15% vs 64%, p = 0.002), and +12 h (7% vs 71%, p < 0.001) as compared to patients with a score of ≤4. Receiver operating characteristics area under the curve was 0.77 at evaluation (95% CI 0.62-0.92; p = 0.001), 0.78 at +6 h (0.66-0.92; p < 0.001), and 0.93 at +12 h (0.86-0.997; p < 0.001). The nSOFA scoring system predicted mortality in VLBW infants with LOS and this automated system was integrated into our EHR. Prediction...Continue Reading

References

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Citations

Mar 4, 2020·Pediatric Research·Matthew McGovernUNKNOWN Infection, Inflammation, Immunology and Immunisation (I4) section of the ESPR
Jul 18, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Catherine DoughtyEleanor J Molloy
Mar 21, 2020·Pediatric Research·Eleanor J MolloyUNKNOWN on behalf of the Infection, Inflammation, Immunology and Immunisation (I4) section of the ESPR
Feb 6, 2021·Archives of Disease in Childhood. Fetal and Neonatal Edition·Irina PrelipceanAngelina Bernier
Jan 28, 2021·International Journal of Environmental Research and Public Health·Gaelle BuryAlain Beuchée
Dec 18, 2020·Frontiers in Pediatrics·Eric Giannoni, Luregn J Schlapbach
Jan 8, 2021·Critical Care : the Official Journal of the Critical Care Forum·Şerife KurulH Rob Taal
Sep 18, 2020·Journal of Pain and Symptom Management·Khyzer B AzizPamela K Donohue
Mar 14, 2021·Journal of Perinatology : Official Journal of the California Perinatal Association·Khyzer B AzizDiomel de la Cruz
Apr 2, 2021·Scientific Reports·Jennifer LeeZachary A Vesoulis
Apr 26, 2021·European Journal of Pediatrics·Walusa Assad Gonçalves-FerriLourenço Sbragia Neto
May 11, 2021·American Journal of Perinatology·Angela C ZeiglerBrynne A Sullivan
May 26, 2021·Clinics in Perinatology·Joseph B Cantey, John H Lee
Jun 26, 2021·Indian Journal of Pediatrics·Adhisivam Bethou, Ballambattu Vishnu Bhat
Jun 25, 2021·The Journal of Pediatrics·Michelle BaczynskiAmish Jain
Sep 9, 2021·Pediatric Research·Brynne A Sullivan, Karen D Fairchild

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Software Mentioned

nSOFA calculator

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