PMID: 9419015Jan 7, 1998Paper

A nestin-negative precursor cell from the adult mouse brain gives rise to neurons and glia

Glia
Valery G KukekovDennis A Steindler

Abstract

Using a novel suspension culture approach, previously undescribed populations of neural precursor cells have been isolated from the adult mouse brain. Recent studies have shown that neuronal and glial precursor cells proliferate within the subependymal zone of the lateral ventricle throughout life, and a persistent expression of developmentally regulated surface and extracellular matrix molecules implicates cell-cell and cell-substrate interactions in the proliferation, migration, and differentiation of these cells. By using reagents that may affect cell-cell interactions, dissociated adult brain yields two types of cell aggregates, type I and type II spheres. Both sphere types are proliferative, and type I spheres evolve into type II spheres. Neurons and glia arise from presumptive stem cells of type II spheres, and they can survive transplantation to the adult brain.

References

Sep 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·L J RichardsP F Bartlett
Jan 1, 1991·Annual Review of Cell Biology·J L Bixby, W A Harris
Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M van de RijnI L Weissman
Oct 1, 1969·Journal of Cellular Physiology·R G WortonJ E Till
Jan 1, 1995·Annual Review of Neuroscience·F H GageL J Fisher
May 1, 1995·Stem Cells·A Alvarez-Buylla, C Lois
Jan 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·B Kirschenbaum, S A Goldman
Jan 1, 1993·Annual Review of Neuroscience·D J Anderson
Jan 1, 1993·Annual Review of Neuroscience·D A Steindler
Dec 5, 1995·Proceedings of the National Academy of Sciences of the United States of America·F H GageJ Ray
Oct 16, 1995·The Journal of Comparative Neurology·M A GatesD A Steindler
Feb 16, 1996·Science·C LoisA Alvarez-Buylla
Nov 1, 1995·Trends in Neurosciences·C N Svendsen, A E Rosser
Sep 1, 1996·Trends in Neurosciences·S WeissD van der Kooy
Jan 1, 1997·Trends in Genetics : TIG·H Lin, T Schagat
Jan 1, 1997·Neuron·D L Stemple, N K Mahanthappa

❮ Previous
Next ❯

Citations

Oct 27, 2004·Cell and Tissue Research·Alexander StorchJohannes Schwarz
Mar 4, 2011·Cell and Tissue Research·Gaetano AzanWilliam R Kennedy
May 12, 2005·Journal of Mammary Gland Biology and Neoplasia·Gabriela Dontu, Max S Wicha
May 18, 2004·Biology of the Cell·Ying Liu, Mahendra S Rao
Dec 4, 2003·Brain Research·Alessandra BezEugenio Agostino Parati
Apr 6, 2004·Brain Research·Melissa J McGinnRaymond J Colello
Mar 31, 2005·Molecular and Cellular Neurosciences·R Mark RichardsonHelen L Fillmore
Jun 25, 2003·Experimental Neurology·S M KearnsD A Steindler
Apr 7, 2000·Brain Research. Brain Research Reviews·R RozentalM F Mehler
Jul 9, 2002·Journal of Neuroscience Methods·Caron M EngstromPeter J Quesenberry
Mar 8, 2000·Journal of Neuroscience Methods·O N SuslovD A Steindler
Jul 10, 2003·Trends in Neurosciences·Larysa Pevny, Mahendra S Rao
Jul 17, 1999·Trends in Neurosciences·B SchefflerD A Steindler
Oct 17, 2002·Proceedings of the National Academy of Sciences of the United States of America·Oleg N SuslovDennis A Steindler
Nov 30, 2000·Proceedings of the National Academy of Sciences of the United States of America·E D LaywellD A Steindler
Mar 1, 2006·Journal of Neurotrauma·Sarah K HagoodRaymond J Colello
Jul 26, 2008·Stem Cells and Development·Mercy VargheseIver A Langmoen
Oct 5, 2010·Tissue Engineering. Part a·Haruko ObokataCharles A Vacanti
Jun 20, 2007·Cerebral Cortex·Irene AppolloniPaolo Malatesta
Aug 21, 2003·The British Journal of Ophthalmology·E J MayerA D Dick
Oct 27, 2004·The Journal of Cell Biology·Anna KowalczykLeszek Kaczmarek
Jun 22, 2005·Neoplasia : an International Journal for Oncology Research·Chengkai DaiEric C Holland
Sep 25, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J Belkind-GersonA M Goldstein
Apr 27, 2013·Cell Biology International·Jinny Jung YoonTrevor Sherwin
Nov 18, 2014·Microscopy Research and Technique·Oleg Tsupykov
Dec 8, 2004·Biochemical and Biophysical Research Communications·Xiaoxia LiLingsong Li
Oct 24, 2007·Biochemical and Biophysical Research Communications·Yong ZhongShuren Zhang
Nov 24, 2004·Biochemical and Biophysical Research Communications·Charles DebrayRoland Pochet
Mar 5, 2004·Expert Opinion on Biological Therapy·Andreas HermannAlexander Storch
Mar 10, 1999·Methods : a Companion to Methods in Enzymology·S GökhanM F Mehler

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.