A Network-Based Approach to Explore the Mechanisms of Uncaria Alkaloids in Treating Hypertension and Alleviating Alzheimer's Disease

International Journal of Molecular Sciences
Wenyong WuWanying Wu

Abstract

Uncaria alkaloids are the major bioactive chemicals found in the Uncaria genus, which have a long history of clinical application in treating cardiovascular and mental diseases in traditional Chinese medicine (TCM). However, there are gaps in understanding the multiple targets, pathways, and biological activities of Uncaria alkaloids. By constructing the interactions among drug-targets-diseases, network pharmacology provides a systemic methodology and a novel perspective to present the intricate connections among drugs, potential targets, and related pathways. It is a valuable tool for studying TCM drugs with multiple indications, and how these multi-indication drugs are affected by complex interactions in the biological system. To better understand the mechanisms and targets of Uncaria alkaloids, we built an integrated analytical platform based on network pharmacology, including target prediction, protein-protein interaction (PPI) network, topology analysis, gene enrichment analysis, and molecular docking. Using this platform, we revealed the underlying mechanisms of Uncaria alkaloids' anti-hypertensive effects and explored the possible application of Uncaria alkaloids in preventing Alzheimer's disease. These results were furt...Continue Reading

References

Jun 1, 1993·The Japanese Journal of Psychiatry and Neurology·H HayakawaM Shimizu
Dec 11, 1999·Nucleic Acids Research·H M BermanP E Bourne
Dec 26, 2001·Nucleic Acids Research·X ChenY Z Chen
Jun 18, 2002·Hospital Medicine·David L Scott
Jul 1, 1961·Biochemical Pharmacology·G L ELLMANR M FEATHER-STONE
May 27, 2004·Phytotherapy Research : PTR·Gerhard Laus
Feb 9, 2007·Nature Biotechnology·Michael J KeiserBrian K Shoichet
Oct 9, 2007·Nature Biotechnology·Andrew L Hopkins
Dec 1, 2007·Nucleic Acids Research·David S WishartMurtaza Hassanali
Oct 22, 2008·Nature Chemical Biology·Andrew L Hopkins
Nov 3, 2009·Nature·Michael J KeiserBryan L Roth
Sep 17, 2011·American Journal of Alzheimer's Disease and Other Dementias·Yuan-Han YangJohn C Morris
Nov 13, 2012·Nucleic Acids Research·Atanas KamburovRalf Herwig
Sep 21, 2013·Bioinformatics·David GfellerVincent Zoete
Sep 21, 2013·Drug Discovery Today. Technologies·Malgorzata N Drwal, Renate Griffith
Jan 2, 2014·Pharmacological Reviews·Gregory SliwoskiEdward W Lowe
Apr 8, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Shao LiWeidong Zhang
Jun 25, 2014·Proceedings of the National Academy of Sciences of the United States of America·Amy K Y FuNancy Y Ip
Sep 2, 2014·BMC Bioinformatics·Philippe BardouChristophe Klopp
Jun 10, 2015·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Daniela CarnevaleBruno Trimarco
Jun 21, 2015·Journal of Ethnopharmacology·Qian ZhangWei Qu
Aug 19, 2015·Briefings in Bioinformatics·Xing ChenYongdong Zhang
Nov 13, 2015·Natural Product Reports·Ling Yi Kong, Ren Xiang Tan
Apr 7, 2016·Annual Review of Neuroscience·Carlo Sala Frigerio, Bart De Strooper
May 12, 2016·Journal of Computer-aided Molecular Design·Zhi-Jiang YaoDong-Sheng Cao
Sep 7, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Maximilian WiesmannJurgen Ahr Claassen
Sep 8, 2016·Neurodegenerative Disease Management·Kristen Dams-O'ConnorAndrew Fedor
Nov 12, 2016·Natural Product Research·Fandong KongYouxing Zhao
Apr 30, 2017·Journal of Alzheimer's Disease : JAD·Ian R MacdonaldSultan Darvesh

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Software Mentioned

GraphPad Prism
ImageGP
SwissTargetPrediction
PhamaMapper
MetaScape
WikiPathways
TargetNet
ConsensusPathDB
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