A network-based signature to predict the survival of non-smoking lung adenocarcinoma

Cancer Management and Research
Qixing MaoLin Xu

Abstract

A substantial increase in the number of non-smoking lung adenocarcinoma (LAC) patients has been drawing extensive attention in the past decade. However, effective biomarkers, which could guide the precise treatment, are still limited for identifying high-risk patients. Here, we provide a network-based signature to predict the survival of non-smoking LAC. Gene expression profiles were downloaded from The Cancer Genome Atlas and Gene Expression Omnibus. Significant gene co-expression networks and hub genes were identified by Weighted Gene Co-expression Network Analysis. Potential mechanisms and pathways of co-expression networks were analyzed by Gene Ontology. The predictive signature was constructed by penalized Cox regression analysis and tested in two independent datasets. Two distinct co-expression modules were significantly correlated with the non-smoking status across 4 Gene Expression Omnibus datasets. Gene Ontology revealed that nuclear division and cell cycle pathways were main mechanisms of the blue module and that genes in the turquoise module were involved in lymphocyte activation and cell adhesion pathways. Seventeen genes were selected from hub genes at an optimal lambda value and built the prognostic signature. The...Continue Reading

Datasets Mentioned

BETA
GSE50081
GSE68465
GSE31210
GSE40419
GSE10072

Software Mentioned

R package “
clusterProfiler
R package “ survivalROC ”
cytoscape
WGCNA
limma ”
R package “ Glmnet ”
R package “ WGCNA
EdgeR ”
Bioconductor

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