A network-based systematic study for the mechanism of the treatment of zhengs related to cough variant asthma

Evidence-based Complementary and Alternative Medicine : ECAM
Di ChenHongjun Yang

Abstract

Traditional Chinese medicine (TCM) has shown significant efficacy in the treatment of cough variant asthma (CVA), a special type of asthma. However, there is shortage of explanations for relevant mechanism of treatment. As Zhengs differentiation is a critical concept in TCM, it is necessary to explain the mechanism of treatment of Zhengs. Based on TCM clinical cases, this study illustrated the mechanism of the treatment of three remarkably relevant Zhengs for CVA: "FengXieFanFei," "FeiQiShiXuan", and "QiDaoLuanJi." To achieve this goal, five steps were carried out: (1) determining feature Zhengs and corresponding key herbs of CVA by analyses of clinical cases; (2) finding out potential targets of the key herbs and clustering them based on their functional annotations; (3) constructing an ingredient-herb network and an ingredient network; (4) identifying modules of the ingredient network; (5) illustrating the mechanism of the treatment by further mining the latent biological implications within each module. The systematic study reveals that the treatment of "FengXieFanFei," "FeiQiShiXuan," and "QiDaoLuanJi" has effects on the regulation of multiple bioprocesses by herbs containing different ingredients with functions of steroid ...Continue Reading

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Citations

Mar 10, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Zhuchen ZhouYuyan Zhang

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Methods Mentioned

BETA
environmental stresses

Software Mentioned

Traditional Medicine Inheritance Support Plat
MCODE
DAVID
MetaDrug
Cytoscape

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