A network meta-analysis of the efficacy and safety of baloxavir marboxil versus neuraminidase inhibitors for the treatment of influenza in otherwise healthy patients

Current Medical Research and Opinion
Vanessa TaiebNobuo Hirotsu

Abstract

Baloxavir marboxil (baloxavir) is the first cap-dependent endonuclease inhibitor being studied for the treatment of influenza in single oral dosing regimen. This network meta-analysis (NMA) evaluated the efficacy and safety of baloxavir compared to other antivirals for influenza in otherwise healthy patients. A systematic literature review was performed on 14 November 2016 in Medline, Embase, CENTRAL, and ICHUSHI to identify randomized controlled trials assessing antivirals for influenza. A NMA including 22 trials was performed to compare the efficacy and safety of baloxavir with other antivirals. The time to alleviation of all symptoms was significantly shorter for baloxavir compared to zanamivir (difference in median time 19.96 h; 95% CrI [3.23, 39.07]). The time to cessation of viral shedding was significantly shorter for baloxavir than zanamivir and oseltamivir (47.00 h; 95% CrI [28.18, 73.86] and 56.03 h [33.74, 87.86], respectively). The mean decline in virus titer from baseline to 24 h was significantly greater for baloxavir than for the other drugs. Other differences in efficacy outcomes were not significant. No significant differences were found between baloxavir and the other antivirals for safety, except total drug-r...Continue Reading

References

Feb 24, 2001·Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases·S KashiwagiI Yoshimura
Sep 5, 2002·Statistics in Medicine·Thomas Lumley
Nov 26, 2002·The Journal of Infectious Diseases·Larisa V GubarevaFrederick G Hayden
Apr 11, 2003·Scandinavian Journal of Infectious Diseases·Tuomo PuhakkaMargaret Tisdale
Sep 21, 2005·Journal of Periodontology·Charles F Hildebolt
Sep 30, 2005·The New England Journal of Medicine·Anne Moscona
Jun 5, 2007·Vaccine·Noelle-Angelique M MolinariCarolyn B Bridges
Dec 4, 2009·Health Technology Assessment : HTA·J BurchS Palmer
Aug 18, 2010·Antimicrobial Agents and Chemotherapy·Shigeru KohnoUNKNOWN S-021812 Clinical Study Group
Oct 5, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jesse PapenburgGuy Boivin
Oct 13, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Akira WatanabeUNKNOWN MARVEL Study Group
Aug 2, 2011·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Leo L M PoonBenjamin J Cowling
Aug 24, 2011·IEEE Transactions on Neural Networks·Francesco Dinuzzo
Jan 20, 2012·The Cochrane Database of Systematic Reviews·Tom JeffersonMatthew J Thompson
Feb 22, 2012·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Shigeki NabeshimaSeizaburo Kashiwagi
Apr 20, 2012·The Cochrane Database of Systematic Reviews·Kay WangAnthony Harnden
Oct 30, 2012·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Sofia DiasNicky J Welton
Feb 6, 2013·The Journal of Infectious Diseases·Lincoln L H LauBenjamin J Cowling
Jun 8, 2013·Journal of Paediatrics and Child Health·Maria Yui Kwan ChowJulie Leask
Dec 5, 2013·Influenza and Other Respiratory Viruses·James E FieldingKathryn Glass
Apr 18, 2015·The Journal of Infectious Diseases·Tim K TsangSimon Cauchemez

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Citations

May 23, 2021·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Yu-Chi KuoCheng-Yi Wang
Dec 18, 2021·Seminars in Respiratory and Critical Care Medicine·Emanuele PalombaAndrea Gori
Dec 24, 2021·Frontiers in Pharmacology·Zhoupeng LiMingkai Li

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