A network of transcriptional repressors modulates auxin responses.

Nature
Jekaterina TruskinaTeva Vernoux

Abstract

The regulation of signalling capacity, combined with the spatiotemporal distribution of developmental signals themselves, is pivotal in setting developmental responses in both plants and animals1. The hormone auxin is a key signal for plant growth and development that acts through the AUXIN RESPONSE FACTOR (ARF) transcription factors2-4. A subset of these, the conserved class A ARFs5, are transcriptional activators of auxin-responsive target genes that are essential for regulating auxin signalling throughout the plant lifecycle2,3. Although class A ARFs have tissue-specific expression patterns, how their expression is regulated is unknown. Here we show, by investigating chromatin modifications and accessibility, that loci encoding these proteins are constitutively open for transcription. Through yeast one-hybrid screening, we identify the transcriptional regulators of the genes encoding class A ARFs from Arabidopsis thaliana and demonstrate that each gene is controlled by specific sets of transcriptional regulators. Transient transformation assays and expression analyses in mutants reveal that, in planta, the majority of these regulators repress the transcription of genes encoding class A ARFs. These observations support a scen...Continue Reading

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Citations

Jan 28, 2021·Trends in Plant Science·Shubhajit DasJan Willem Borst
Mar 23, 2021·Frontiers in Plant Science·Mónica L García-GómezElena R Álvarez-Buylla
Jun 9, 2021·Nature Plants·Teva VernouxChristophe Godin
May 22, 2021·Frontiers in Plant Science·Laura Serrano-RonMiguel A Moreno-Risueno
Apr 28, 2021·Cold Spring Harbor Perspectives in Biology·Yanfei MaJan U Lohmann

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Datasets Mentioned

BETA
GSE19654
E-MTAB-4684
GSM1289374
GSM2260236
GSM2719205
GSE60141

Methods Mentioned

BETA
one-hybrid
affinity
immunoprecipitation
transgenic
PCR

Software Mentioned

Bedtools
Rootnav
IGV
ImageJ
R script
SAM
ArrayExpress

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