A Network Pharmacology Approach to Explore Mechanism of Action of Longzuan Tongbi Formula on Rheumatoid Arthritis

Evidence-based Complementary and Alternative Medicine : ECAM
An HuangZongran Pang

Abstract

Longzuan Tongbi Formula (LZTB) is an effective proved prescription in Zhuang medicine for treating active rheumatoid arthritis (RA). However, its active ingredients, underlying targets, and pharmacological mechanism are still not clear in treating RA. We have applied network pharmacology to study LZTB and found that 8 herbs in LZTB and 67 compounds in the 8 herbs are involved in the regulation of RA-related genes; we have conducted pathway analysis of overlapping genes and found that 7 herbs participate in the regulations of 24 pathways associated with RA and that 5 herbs in the 7 herbs and 25 compounds in the 5 herbs participate in the regulation of hsa05323 (rheumatoid arthritis). The results indicated that all herbs in LZTB and some compounds in those herbs participate in the treatment of RA; 25 compounds are main active ingredients and hsa05323 (rheumatoid arthritis) is the major pathway in the treatment of RA. We have also found that three pathways (inflammatory mediator regulation of TRP channels, PPAR signaling pathway, and mTOR signaling pathway) might have some effect on the treatment of RA.

References

Mar 23, 2004·BMJ : British Medical Journal·Lorna MasonHenry J McQuay
Apr 7, 2006·American Journal of Physiology. Cell Physiology·Mikhail Y KochukovKarin N Westlund
Oct 21, 2006·Biochemical Society Transactions·K A ReedquistP P Tak
Jan 4, 2008·Nature·Shang-Zhong XuDavid J Beech
Oct 22, 2008·Nature Chemical Biology·Andrew L Hopkins
Dec 18, 2010·Nature Reviews. Genetics·Albert-László BarabásiJoseph Loscalzo
Mar 16, 2011·Genome Biology·Bernd Nilius, Grzegorz Owsianik
Jan 4, 2012·Annals of the New York Academy of Sciences·Susan D Brain
Mar 30, 2012·Omics : a Journal of Integrative Biology·Guangchuang YuQing-Yu He
Jul 31, 2012·Cytokine·Anupam MitraSiba P Raychaudhuri
Jun 6, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Leihong WuYiyu Cheng
Jun 22, 2013·Chinese Journal of Natural Medicines·Shao Li, Bo Zhang
May 6, 2015·Biochimica Et Biophysica Acta·Tarik SmaniJuan A Rosado
Apr 26, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Huaqi TangYikun Sun
Oct 30, 2016·Lancet·Josef S SmolenIain B McInnes
Jun 3, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Mirjam N TrameJerome T Mettetal
Dec 8, 2016·Nucleic Acids Research·Damian SzklarczykChristian von Mering
Jan 12, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Huiping LiuGuomin Zhang
Jun 15, 2017·Lancet·Gerd R Burmester, Janet E Pope
Apr 26, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Kailin YangJinwen Ge

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Citations

Jan 24, 2020·International Immunopharmacology·Xinqiang SongHongtao Du

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Software Mentioned

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