A network pharmacology study on the triterpene saponins from Medicago sativa L. for the treatment of Neurodegenerative diseases

Journal of Food Biochemistry
Xue-Gui LiuDan-Qi Li

Abstract

Neurodegenerative diseases (NDDs) are characterized by progressive and irreversible, is a kind of complex illnesses, and the long-term therapy which is frequently associated with adverse side effects. Medicago sativa L., widely consumed as a vegetable, has the effects of improving memory and relieving central nervous system diseases. However, there are less studies on its specific mechanism for NDDs. In this investigation, we applied a method of network pharmacology, which combined molecular docking and network analysis to decipher the mechanisms of M. sativa in NDDs. The pharmacological system generated 55 triterpene saponins from M. sativa, and predicted 27 potential targets with 100 pathways in the treatment of NDDs. As a result, 13 compounds, 10 target proteins, and 6 signaling pathways were found to play important roles in the treatment of NDDs. In addition, in vitro experiments of isolates confirmed activities for NDDs, which were consistent with the results of network pharmacology prediction. PRACTICAL APPLICATIONS: Medicago sativa L. has been widely consumed as a vegetable, which possesses many nutritional components. As a functional food stuff, M. sativa can improve human health, such as memory improving activities, re...Continue Reading

References

Dec 1, 1992·Chemical & Pharmaceutical Bulletin·B CuiT Nohara
Apr 4, 1997·Journal of Molecular Biology·G JonesR Taylor
Nov 14, 1997·The Biochemical Journal·P MassonO Lockridge
Dec 20, 1999·Journal of Agricultural and Food Chemistry·Z BialyC Pizza
Oct 3, 2000·Phytochemistry·S M Abdel KhalikF R Melek
May 17, 2002·Journal of Medicinal Chemistry·Thompson N DomanBrian K Shoichet
Jun 1, 2005·Journal of Chemical Information and Modeling·Robert N Jorissen, Michael K Gilson
Nov 4, 2006·Science·Michel Goedert, Maria Grazia Spillantini
May 22, 2007·Biochemical Society Transactions·J H Stockley, C O'Neill
Dec 1, 2007·Nucleic Acids Research·David S WishartMurtaza Hassanali
Aug 20, 2009·Journal of Chemical Information and Modeling·X H LiuY Z Chen
Dec 15, 2010·Bioinformatics·Michael E SmootTrey Ideker
May 25, 2011·Journal of Medicinal Chemistry·Fabiana CaporuscioAlberto Del Rio
Jul 26, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Kundan Singh Bora, Anupam Sharma
Aug 30, 2011·Journal of Chemical Information and Modeling·G Madhavi SastryWoody Sherman
Feb 22, 2012·Advances in Experimental Medicine and Biology·Barbara PicconiPaolo Calabresi
Mar 22, 2012·BMC Systems Biology·Aihua ZhangXijun Wang
Apr 27, 2012·Frontiers in Molecular Neuroscience·Akihiko Takashima
Nov 8, 2012·Nature Methods·Rintaro SaitoTrey Ideker
Jan 2, 2013·Therapeutic Advances in Neurological Disorders·Konstantina G Yiannopoulou, Sokratis G Papageorgiou
Feb 1, 2014·Natural Product Reports·Azra GholamiAlain Goossens
Mar 26, 2014·ACS Nano·Meir GoldsmithDan Peer
Jul 15, 2015·Environmental Toxicology and Pharmacology·Xiao-Long HuQing-Chun Zhao
Oct 20, 2015·Combinatorial Chemistry & High Throughput Screening·Uma ChandranBhushan Patwardhan
Oct 29, 2015·Critical Reviews in Food Science and Nutrition·Laura CornaraBruno Burlando
Feb 18, 2016·Bioorganic & Medicinal Chemistry Letters·Dan-Qi LiChun-Fu Wu
Nov 3, 2016·Journal of Agricultural and Food Chemistry·Qin-Ge MaZhong-Wen Song
Nov 23, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Fabiola M RibeiroStephen S G Ferguson
Jun 7, 2017·Life Sciences·Janaína Niero MazonGislaine Tezza Rezin
Jun 2, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Xinkui LiuXiaomeng Zhang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Die Pharmazie
K HillerB Linzer
Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
Richard W Weber
© 2021 Meta ULC. All rights reserved