A neural command circuit for grooming movement control

ELife
Stefanie HampelAndrew M Seeds

Abstract

Animals perform many stereotyped movements, but how nervous systems are organized for controlling specific movements remains unclear. Here we use anatomical, optogenetic, behavioral, and physiological techniques to identify a circuit in Drosophila melanogaster that can elicit stereotyped leg movements that groom the antennae. Mechanosensory chordotonal neurons detect displacements of the antennae and excite three different classes of functionally connected interneurons, which include two classes of brain interneurons and different parallel descending neurons. This multilayered circuit is organized such that neurons within each layer are sufficient to specifically elicit antennal grooming. However, we find differences in the durations of antennal grooming elicited by neurons in the different layers, suggesting that the circuit is organized to both command antennal grooming and control its duration. As similar features underlie stimulus-induced movements in other animals, we infer the possibility of a common circuit organization for movement control that can be dissected in Drosophila.

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Citations

Jun 23, 2016·Journal of Neurogenetics·Benjamin H White
Jul 23, 2016·Frontiers in Physiology·Shigehiro Namiki, Ryohei Kanzaki
Feb 18, 2017·ELife·Olivia SchwarzJan Pielage
Jul 15, 2017·Cell·Alice A RobieKristin Branson
Nov 10, 2017·Nature·Nathan C KlapoetkeGwyneth M Card
Nov 18, 2017·BMC Veterinary Research·Zoe R NalborczykClare Rusbridge
Aug 21, 2018·ELife·Romain FranconvilleVivek Jayaraman
Nov 18, 2018·The Journal of Experimental Biology·Mehmet F KeleşMark A Frye
Jun 4, 2020·ELife·Anthony W AzevedoJohn C Tuthill
Jul 31, 2020·G3 : Genes - Genomes - Genetics·Aya YanagawaTrudy F C Mackay
Feb 8, 2019·The Journal of Experimental Biology·Timothy L WarrenMichael H Dickinson
May 17, 2018·Learning & Memory·Christian KönigAyse Yarali
Apr 6, 2018·Genetics·Julie H Simpson, Loren L Looger
Jan 21, 2021·Communications Biology·Budhaditya ChowdhuryHerman A Dierick
Nov 27, 2020·Frontiers in Neural Circuits·Haojiang LuanBenjamin H White
Sep 4, 2018·Current Biology : CB·Ysabel Milton GiraldoMichael H Dickinson
Aug 28, 2021·Cells·Nelly RedolfiDiana Pendin

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Methods Mentioned

BETA
transgenic
amputation

Software Mentioned

LexA
MATLAB
Fiji
FluoRender
aJO
Computations Morphometry Toolkit CMTK
neuTube
VCode

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