A neural pathway controlling motivation to exert effort

Proceedings of the National Academy of Sciences of the United States of America
Christophe D ProulxRoberto Malinow

Abstract

The neural mechanisms conferring reduced motivation, as observed in depressed individuals, is poorly understood. Here, we examine in rodents if reduced motivation to exert effort is controlled by transmission from the lateral habenula (LHb), a nucleus overactive in depressed-like states, to the rostromedial tegmental nucleus (RMTg), a nucleus that inhibits dopaminergic neurons. In an aversive test wherein immobility indicates loss of effort, LHb→RMTg transmission increased during transitions into immobility, driving LHb→RMTg increased immobility, and inhibiting LHb→RMTg produced the opposite effects. In an appetitive test, driving LHb→RMTg reduced the effort exerted to receive a reward, without affecting the reward's hedonic property. Notably, LHb→RMTg stimulation only affected specific aspects of these motor tasks, did not affect all motor tasks, and promoted avoidance, indicating that LHb→RMTg activity does not generally reduce movement but appears to carry a negative valence that reduces effort. These results indicate that LHb→RMTg activity controls the motivation to exert effort and may contribute to the reduced motivation in depression.

References

Jan 1, 1979·Neuroscience and Biobehavioral Reviews·K A Roth, R J Katz
May 1, 1973·Animal Behaviour·J Archer
Nov 5, 1998·Pharmacology, Biochemistry, and Behavior·J E AbermanJ D Salamone
Mar 5, 2003·Hormones and Behavior·Karen J ParkerDavid M Lyons
Mar 10, 2004·Behavioral and Cognitive Neuroscience Reviews·J Shumake, F Gonzalez-Lima
Jun 1, 2005·Behavioural Brain Research·Rafal RygulaUrsula Havemann-Reinecke
Jan 24, 2006·Nature Reviews. Neuroscience·Olivier Berton, Eric J Nestler
Mar 29, 2006·Biological Psychiatry·Eric J Nestler, William A Carlezon
Apr 25, 2006·Biological Psychiatry·Ronald S Duman, Lisa M Monteggia
Aug 24, 2006·Neuropharmacology·Charles D KopecRoberto Malinow
Apr 11, 2007·Molecular Psychiatry·J Mill, A Petronis
May 25, 2007·Nature·Masayuki Matsumoto, Okihide Hikosaka
Aug 30, 2007·Nature Neuroscience·Amar Sahay, Rene Hen
Sep 14, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Christopher Pittenger, Ronald S Duman
Dec 2, 2008·Nature Neuroscience·Masayuki Matsumoto, Okihide Hikosaka
Oct 23, 2009·Biological Psychiatry·Alexander SartoriusAndreas Meyer-Lindenberg
Jul 7, 2010·Neuroscience and Biobehavioral Reviews·Michael T Treadway, David H Zald
Dec 15, 2010·Neuron·Ethan S Bromberg-MartinOkihide Hikosaka
Aug 13, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Simon HongOkihide Hikosaka
May 4, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael T TreadwayDavid H Zald
Jun 26, 2012·Nature Neuroscience·Alice M Stamatakis, Garret D Stuber
Oct 12, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michel BarrotThomas C Jhou
Nov 13, 2012·Neuron·John D Salamone, Mercè Correa
Jul 23, 2013·Nature·Tsai-Wen ChenDouglas S Kim
Apr 10, 2014·The European Journal of Neuroscience·Salvatore LeccaManuel Mameli
Aug 27, 2014·Nature Neuroscience·Christophe D ProulxRoberto Malinow
Dec 2, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·John D SalamonePhilip McGuire
Sep 26, 2015·Nature Neuroscience·Nick G HollonPaul E M Phillips
Nov 26, 2015·Nature Neuroscience·Arif A HamidJoshua D Berke
Jan 14, 2016·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alice M StamatakisGarret D Stuber

❮ Previous
Next ❯

Citations

Jun 4, 2019·Proceedings of the National Academy of Sciences of the United States of America·Steven J ShabelRoberto Malinow
Jul 16, 2019·Psychiatry and Clinical Neurosciences·Kenji F Tanaka, Takuya Hamaguchi
Oct 22, 2019·The European Journal of Neuroscience·Tom BiselliAndreas Walther
Jan 21, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kevin R CoffeyJohn F Neumaier
Sep 18, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hikaru ItoHidenori Aizawa
Mar 10, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ting LeiHua Zhao
Dec 26, 2018·Frontiers in Synaptic Neuroscience·Caroline A BrowneIrwin Lucki
Jan 17, 2020·Proceedings of the National Academy of Sciences of the United States of America·Matthew E KleinRoberto Malinow
Apr 10, 2020·Nature Reviews. Neuroscience·Hailan HuYan Yang
Jan 11, 2020·Frontiers in Behavioral Neuroscience·Blake Porter, Kristin L Hillman
Feb 6, 2019·Cold Spring Harbor Symposia on Quantitative Biology·Yihui CuiHailan Hu
Dec 22, 2020·Neurobiology of Stress·Sarah C SimmonsFereshteh S Nugent
Nov 19, 2019·Behavioural Brain Research·Amanda M HaskellRichard J Servatius
Dec 22, 2020·Neurobiology of Stress·Marjorie R LevinsteinJohn F Neumaier
Nov 5, 2020·International Journal of Molecular Sciences·Chaya ShorJiang-Hong Ye
Mar 23, 2021·Frontiers in Molecular Neuroscience·Chengxi LiuMazhong Zhang
Sep 6, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Marc Fakhoury
Aug 11, 2021·Neuropharmacology·Adam Gordon-Fennell, Garret D Stuber

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.