A neurodevelopmental origin of behavioral individuality in the Drosophila visual system.

Science
Gerit Arne LinneweberBassem Hassan

Abstract

The genome versus experience dichotomy has dominated understanding of behavioral individuality. By contrast, the role of nonheritable noise during brain development in behavioral variation is understudied. Using Drosophila melanogaster, we demonstrate a link between stochastic variation in brain wiring and behavioral individuality. A visual system circuit called the dorsal cluster neurons (DCN) shows nonheritable, interindividual variation in right/left wiring asymmetry and controls object orientation in freely walking flies. We show that DCN wiring asymmetry instructs an individual's object responses: The greater the asymmetry, the better the individual orients toward a visual object. Silencing DCNs abolishes correlations between anatomy and behavior, whereas inducing DCN asymmetry suffices to improve object responses.

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Citations

Aug 22, 2020·Médecine sciences : M/S·Mahéva Andriatsilavo, Bassem Hassan
Sep 19, 2020·Science·James Briscoe, Oscar Marín
Jul 18, 2020·The Journal of Comparative Neurology·Gesa F DingesAnsgar Büschges
Nov 5, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·P Robin Hiesinger
Nov 17, 2020·Frontiers in Psychology·Krisztina Sándor, Ádám Miklósi
Jan 1, 2021·PloS One·John A BogovicStephan Saalfeld
Apr 14, 2021·Scientific Reports·Bastien S LemaireElisabetta Versace

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