A neuroendocrine test battery in bipolar patients and healthy subjects

Archives of General Psychiatry
J D AmsterdamK Rickels

Abstract

Abnormalities of hormonal responses to a number of neuroendocrine challenges have been reported in depressed patients. Most studies have examined responses in a single neuroendocrine axis. We used a series of four neuroendocrine challenges (thyrotropin-releasing hormone test, gonadotropin-releasing hormone test, insulin tolerance test, and dexamethasone suppression test) to examine eight hormonal responses in 22 healthy subjects and 22 patients with bipolar disorder. Variability of hormonal responses in bipolar patients was examined by evaluating the number of abnormal hormonal responses as compared with responses from healthy volunteers. Abnormalities were observed after all four neuroendocrine tests. Nine control subjects (40.9%) and 17 bipolar patients (77.3%) had at least one abnormal response. More strikingly, 12 bipolar patients (54.5%), but no controls, had two or more abnormal responses. These findings suggest that manic-depressive patients show increased variability in hormonal response from multiple neuroendocrine axes.

Citations

Oct 8, 1999·Journal of Affective Disorders·J AmsterdamC Beasley
Jan 1, 1992·Psychiatry Research·R G KatholB M Sherman
Jan 1, 1985·European Archives of Psychiatry and Neurological Sciences·C M BankiZ Kovacs
Mar 28, 2013·Expert Opinion on Medical Diagnostics·Antonio Lucio TeixeiraMoisés E Bauer
Nov 9, 2015·Psychoneuroendocrinology·Martino Belvederi MurriMario Amore
Jul 14, 2007·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Michael SegalAbraham Weizman
Feb 1, 1987·Biological Psychiatry·J F LopezW Meller
Aug 1, 1986·Metabolism: Clinical and Experimental·H R FishJ T O'Brian
Oct 1, 1984·Acta Psychiatrica Scandinavica·C M BankiZ Papp
Aug 12, 2014·Psychoneuroendocrinology·Leah GirshkinMelissa J Green
Nov 14, 2006·Journal of Affective Disorders·Fernando ContrerasGordon Parker
May 21, 2013·Psychoneuroendocrinology·Fabrice DuvalMarc-Antoine Crocq
Jun 1, 1985·The Australian and New Zealand Journal of Psychiatry·G W MellsopM E Vijayasenan
Aug 1, 1988·Acta Psychiatrica Scandinavica·F UndénL Wetterberg
Oct 31, 2002·Human Psychopharmacology·Albert Michael, Veronica O'Keane
Feb 26, 2016·F1000Research·Darius Becker-Krail, Colleen McClung
Jan 1, 1989·European Archives of Psychiatry and Neurological Sciences·R T Rubin
Apr 1, 1987·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·W H NormanG I Keitner
Apr 1, 1984·The British Journal of Psychiatry : the Journal of Mental Science·G W MellsopM E Vijayasenan
May 1, 1984·The British Journal of Psychiatry : the Journal of Mental Science·C M Banki, M Arato
Nov 1, 1988·La Revue de médecine interne·P Lemoine

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