PMID: 2507160Sep 1, 1989Paper

A neuroendocrinological study in female migraineurs: prolactin and thyroid stimulating hormone responses

Cephalalgia : an International Journal of Headache
E AwakiK Takahashi

Abstract

To evaluate the change of the neurotransmitter function in migraine, a neuroendocrinological study was performed in eleven female migraineurs and nine female controls. Thyrotropin releasing hormone, luteinizing hormone releasing hormone, and insulin were simultaneously loaded (the Triple test). Before and after loading, serum glucose, prolactin (PRL), thyroid stimulating hormone (TSH), luteinizing hormone, follicle stimulating hormone, adrenocorticotropic hormone, cortisol, human growth hormone and beta-endorphin were measured. The Triple test produced an increase of PRL in both migraine and control groups, but in migraineurs the increase was significantly larger than in controls. TSH also increased in response to the test, but the TSH response in patients was less than in controls, although not significantly so. The responses of other substances showed no significant differences between the two groups. Although dopaminergic hypofunction in migraine has been proposed by some authors, the present findings rather suggest a serotonergic hyperfunction.

Citations

Jan 11, 2002·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·K HagenG Bovim
Sep 22, 2000·Cephalalgia : an International Journal of Headache·L PinessiE Arvat
Jul 27, 2001·Cephalalgia : an International Journal of Headache·R H KemperG J Ter Horst
Jan 22, 2003·Cephalalgia : an International Journal of Headache·E M CassidyV O'Keane
Apr 24, 2007·Cephalalgia : an International Journal of Headache·B L PeterlinA M Rapoport
Feb 19, 2016·Cephalalgia : an International Journal of Headache·Robin M van DongenMichel D Ferrari
Aug 15, 2018·Cephalalgia : an International Journal of Headache·Natalia L StarikovaTatiana P Kalashnikova
Mar 13, 1998·Cephalalgia : an International Journal of Headache·C BenedettoC De Lorenzo
Jul 2, 2021·The European Journal of Neuroscience·Willebrordus P J van OosterhoutMark C Kruit

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