A Neuroimaging Marker Based on Diffusion Tensor Imaging and Cognitive Impairment Due to Cerebral White Matter Lesions

Frontiers in Neurology
Na WeiYongjun Wang

Abstract

Background: The peak width of skeletonized mean diffusivity (PSMD) is a new, fully automated, robust imaging marker for cerebral small vessel disease (SVD), strongly associated with processing speed. However, it has never been applied to cerebral white matter lesions (WMLs). Our study aimed to investigate the correlation between PSMD and cognition, particularly in the executive function of patients with WMLs. Methods: A total of 111 WML patients and 50 healthy controls (HCs) were enrolled, and their demographic information and cardiovascular disease risk factors were recorded. Subjects were divided into three groups: WMLs with normal cognition (WMLs-NC), WMLs with vascular cognitive impairment (WMLs-VCI), and HCs. They underwent conventional head magnetic resonance imaging and diffusion tensor imaging (DTI), followed by neuropsychological and psychological examinations, including the Montreal Cognitive Assessment (MoCA), and the executive function tests. We compared executive function and PSMD among the three groups and analyzed the correlation between PSMD and cognitive function in all subjects. Results: There were no significant differences in demographic characteristics (age, sex, education level, and cardiovascular disease ...Continue Reading

References

Jan 1, 1987·Archives of Neurology·V C HachinskiH Merskey

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Citations

Nov 9, 2019·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Bonnie Yin Ka LamVincent Chung Tong Mok
Apr 9, 2020·Frontiers in Neuroscience·Audrey LowJohn T O'Brien
Aug 14, 2019·Frontiers in Psychiatry·Ian J DearyMark E Bastin
Feb 26, 2021·Current Opinion in Neurology·Maria Clara Zanon ZotinPinar Yilmaz
Sep 14, 2020·Brain, Behavior, and Immunity·Gemma SullivanJames P Boardman

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Software Mentioned

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Functional Magnetic Resonance Imaging of the Brain ( FMRIB ) l...
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