PMID: 9426749Jan 14, 1998Paper

A neurologic basis for the overactive bladder

Urology
W C de Groat

Abstract

The functions of the lower urinary tract (LUT) to store and periodically release urine are dependent on neural circuits in the brain and spinal cord. This paper reviews the central neural control of micturition and how disruption of this control can lead to bladder overactivity and incontinence. Neuroanatomic, electrophysiologic, and pharmacologic techniques have provided information about the neural circuitry and the neurotransmitters involved in the central nervous control of voiding. Experimental models of neural injury, including spinal cord transection, cerebral infarction, and localized brain lesions, have been studied to identify the mechanisms contributing to the neurogenic overactive bladder. Normal storage of urine is dependent on 1) spinal reflex mechanisms that activate sympathetic and somatic pathways to the urethral outlet and 2) tonic inhibitory systems in the brain that suppress the parasympathetic excitatory outflow to the urinary bladder. Voiding is mediated by inhibition of sympathetic-somatic pathways and activation of a spinobulbospinal parasympathetic reflex pathway passing through a micturition center in the rostral pons. Damage to the brain can induce bladder overactivity by reducing suprapontine inhibit...Continue Reading

References

Apr 11, 1975·Brain Research·W C De Groat
Apr 19, 1991·Brain Research·B S MalloryW C de Groat
Nov 1, 1991·The Journal of Clinical Investigation·W D SteersJ B Tuttle
Jul 1, 1990·Journal of the Autonomic Nervous System·W C de GroatJ R Roppolo
Aug 1, 1990·The Journal of Physiology·M FallL Mazières
Oct 8, 1989·The Journal of Comparative Neurology·K B ThorW C De Groat
Apr 22, 1988·Neuroscience Letters·A AlbaneseJ D Stephenson
Jul 15, 1987·Experientia·W C de Groat
Oct 1, 1987·Pflügers Archiv : European journal of physiology·E BahnsW Jänig
Jan 1, 1969·The Journal of Physiology·W C de Groat, R W Ryall
Apr 1, 1981·Journal of the Autonomic Nervous System·W C de GroatK Thor
Sep 5, 1995·Journal of the Autonomic Nervous System·M N KruseW C de Groat
Apr 1, 1995·British Journal of Pharmacology·G T SomogyiW C de Groat
Jun 1, 1995·The Journal of Urology·B C BennettW C de Groat
Feb 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·C J FowlerC G Fowler
Feb 1, 1994·The Journal of Urology·G GeirssonK Hjälmås
Jun 1, 1993·British Journal of Urology·G GeirssonM Fall
Jun 1, 1993·British Journal of Urology·G GeirssonS Lindström
Feb 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·M S GoldJ D Levine
Jan 1, 1997·Brain : a Journal of Neurology·B F BlokG Holstege
Mar 1, 1997·International Journal of Urology : Official Journal of the Japanese Urological Association·N Yoshimura, W C de Groat
Apr 23, 1999·Neuroscience Letters·L Sha, J H Szurszewski
Nov 1, 1956·The Journal of Comparative Neurology·T C RUCH, P C TANG

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Citations

May 13, 1999·The Journal of Comparative Neurology·C W MorganD E Scott
May 8, 2000·Neurourology and Urodynamics·F van DuinA van Oosterom
Feb 9, 2002·Neurourology and Urodynamics·Lars Viktrup
Jun 8, 2006·Der Urologe. Ausg. A·S Schumacher
Mar 16, 2007·Der Urologe. Ausg. A·S Schumacher
Aug 1, 2007·Der Urologe. Ausg. A·W Kummer
Apr 9, 2010·Der Urologe. Ausg. A·C HampelR Gillitzer
Oct 17, 2008·International Urogynecology Journal and Pelvic Floor Dysfunction·Lior LowensteinKimberly Kenton
Oct 26, 2010·International Urogynecology Journal·Mohamed S ElkeliniMagdy M Hassouna
Jan 17, 2012·International Urogynecology Journal·Joy A GreerLily A Arya
Sep 15, 2012·International Urogynecology Journal·Kelly Jirschele, Peter K Sand
May 25, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·António Avelino, Francisco Cruz
Jan 21, 2006·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Jasmin Katrin BadawiStephan Bross
Nov 12, 2010·International Journal of Colorectal Disease·John M Findlay, Charles Maxwell-Armstrong
Sep 1, 2005·Annals of Biomedical Engineering·Jiro NagatomiMichael S Sacks
Apr 14, 2010·Annals of Biomedical Engineering·Atheer M AlmasriJohn E Speich
Nov 12, 2002·Current Urology Reports·Christina Kwon, Peter K Sand
Jan 22, 2004·Current Urology Reports·George J Christ
Oct 21, 2006·Current Urology Reports·Casey K NgAlexis E Te
Jan 24, 2007·Current Urology Reports·Scott MacDiarmid, Alexandra Rogers
Jan 31, 2008·Reviews in Urology·Herbert Lepor
Oct 30, 2009·Current Urology Reports·O James Ekundayo
Dec 3, 2010·Current Urology Reports·Doreen E Chung, Jaspreet S Sandhu
Jul 3, 2013·Current Urology Reports·Jamie M BartleyKenneth M Peters
May 15, 2002·Urology·Francisco Cruz
Jan 14, 1998·Urology·A F Brading
Nov 5, 1999·Trends in Pharmacological Sciences·O Sterner, A Szallasi
Apr 18, 2002·Neurobiology of Aging·Kenneth G Pugh, Lewis A Lipsitz
Sep 23, 2003·European Urology·Rikard PehrsonKarl Erik Andersson
Jul 10, 2003·Lancet Neurology·Arpad Szallasi, Clare J Fowler
May 21, 2008·Nature Reviews. Neuroscience·Clare J FowlerWilliam C de Groat
Oct 12, 2010·Nature Reviews. Urology·Dev M Gulur, Marcus J Drake
Aug 25, 2007·International Journal of Impotence Research·A F BradingH Hashitani
Nov 26, 2002·BJU International·K-E Andersson
Oct 16, 2004·Public Health Nutrition·Helen M DallossoUNKNOWN Leicestershire MRC Incontinence Study Group

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