A neuronal mechanism underlying decision-making deficits during hyperdopaminergic states

Nature Communications
Jeroen P H VerharenLouk Jmj Vanderschuren

Abstract

Hyperdopaminergic states in mental disorders are associated with disruptive deficits in decision making. However, the precise contribution of topographically distinct mesencephalic dopamine pathways to decision-making processes remains elusive. Here we show, using a multidisciplinary approach, how hyperactivity of ascending projections from the ventral tegmental area (VTA) contributes to impaired flexible decision making in rats. Activation of the VTA-nucleus accumbens pathway leads to insensitivity to loss and punishment due to impaired processing of negative reward prediction errors. In contrast, activation of the VTA-prefrontal cortex pathway promotes risky decision making without affecting the ability to choose the economically most beneficial option. Together, these findings show how malfunction of ascending VTA projections affects value-based decision making, suggesting a potential mechanism through which increased forebrain dopamine signaling leads to aberrant behavior, as is seen in substance abuse, mania, and after dopamine replacement therapy in Parkinson's disease.

References

Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G Di Chiara, A Imperato
Oct 1, 1983·Brain Research·R J Beninger
Mar 14, 1997·Science·W SchultzP R Montague
Apr 3, 2001·Annual Review of Neuroscience·E K Miller, J D Cohen
May 16, 2001·Psychological Medicine·F C MurphyB J Sahakian
May 30, 2002·Neuroscience and Biobehavioral Reviews·Rudolf N CardinalBarry J Everitt
Jul 13, 2004·Current Opinion in Neurology·Andrew H Evans, Andrew J Lees
Jul 24, 2004·Trends in Neurosciences·Pieter VoornCyriel M A Pennartz
Nov 6, 2004·Science·Michael J FrankRandall C O'reilly
Jan 12, 2005·Clinical Psychology Review·Sheri L Johnson
Mar 12, 2005·Science·Philippe N ToblerWolfram Schultz
Feb 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Elyssa B MargolisHoward L Fields
Nov 16, 2006·PLoS Medicine·Christian Lüscher, Mark A Ungless
Mar 23, 2007·Annual Review of Neuroscience·Howard L FieldsSaleem M Nicola
Oct 19, 2007·Acta Psychiatrica Scandinavica. Supplementum·M BerkT Norman
Nov 8, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Birgit AblerStephan Heckers
Mar 6, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Desirae M Haluk, Stan B Floresco
Jun 19, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Fiona D ZeebCatharine A Winstanley
Jun 10, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jennifer R St OngeStan B Floresco
Dec 2, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nicholas W SimonBarry Setlow
Feb 24, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jennifer R St OngeStan B Floresco
Mar 27, 2012·Neuron·Ruud van ZessenGarret D Stuber
Aug 15, 2012·Psychiatry Research·Jakob LinnetAlbert Gjedde
Nov 13, 2012·Neuron·John D Salamone, Mercè Correa
Jan 11, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Colin M StopperStan B Floresco
Feb 12, 2013·Current Opinion in Neurobiology·Xavier NoëlAntoine Bechara
Apr 13, 2013·Neuropharmacology·Stephan LammelRobert C Malenka
May 28, 2013·Nature Neuroscience·Elizabeth E SteinbergPatricia H Janak
Nov 26, 2013·Neuron·Hanneke E M den OudenRoshan Cools
Jun 21, 2014·Cell·Lisa A GunaydinKarl Deisseroth

❮ Previous
Next ❯

Citations

Mar 15, 2019·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Jeroen P H VerharenLouk J M J Vanderschuren
Jun 30, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jeroen P H VerharenLouk J M J Vanderschuren
Oct 12, 2019·Brain : a Journal of Neurology·Brónagh McCoyJan Theeuwes
Jan 16, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Júlia Sala-BayoTrevor W Robbins
Feb 7, 2020·Psychopharmacology·Jeroen P H VerharenLouk J M J Vanderschuren
Oct 12, 2018·Psychopharmacology·Benjamin U PhillipsTimothy J Bussey
Mar 30, 2020·Psychopharmacology·Jeroen P H VerharenRoger A H Adan
Feb 2, 2019·Scientific Reports·Jeroen P H VerharenRoger A H Adan
Jan 20, 2020·Neuroscience Research·Yuichi Takeuchi, Antal Berényi
Oct 23, 2018·Neuropsychologia·Samuel J Gershman, Bastian Greshake Tzovaras
Aug 18, 2021·Experimental Neurology·Vito S HernándezLimei Zhang

❮ Previous
Next ❯

Methods Mentioned

BETA
transfection

Software Mentioned

GraphPad Prism
Ethovision
Clarity
MATLAB
GraphPad
fmincon
MedPC

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

© 2022 Meta ULC. All rights reserved