A neuronal molecular switch through cell-cell contact that regulates quiescent neural stem cells

Science Advances
Jian DongNan-Jie Xu

Abstract

The quiescence of radial neural stem cells (rNSCs) in adult brain is regulated by environmental stimuli. However, little is known about how the neurogenic niche couples the external signal to regulate activation and transition of quiescent rNSCs. Here, we reveal that long-term excitation of hippocampal dentate granule cells (GCs) upon voluntary running leads to activation of adult rNSCs in the subgranular zone and thereby generation of newborn neurons. Unexpectedly, the role of these excited GC neurons in NSCs depends on direct GC-rNSC interaction in the local niche, which is through down-regulated ephrin-B3, a GC membrane-bound ligand, and attenuated transcellular EphB2 kinase-dependent signaling in the adjacent rNSCs. Furthermore, constitutively active EphB2 kinase sustains the quiescence of rNSCs during running. These findings thus elucidate the physiological significance of GC excitability on adult rNSCs under external environments and indicate a key-lock switch regulation via cell-cell contact for functional transition of rNSCs.

References

Nov 11, 1998·Nature Medicine·P S ErikssonF H Gage
Feb 20, 2002·Trends in Neurosciences·Bernd Knöll, Uwe Drescher
Jan 28, 2003·Neuron·Hsiao-Huei WuAnne L Calof
Sep 16, 2003·Neuron·Scott E WilliamsMark Henkemeyer
Mar 24, 2004·Cell·Elaine FuchsGeraldine Guasch
Mar 25, 2005·Genesis : the Journal of Genetics and Development·Tzong-Shiue YuSteven G Kernie
Nov 16, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Diane C LagaceAmelia J Eisch
Oct 29, 2008·Nature Neuroscience·Ryoichiro KageyamaItaru Imayoshi
Feb 3, 2009·Nature Neuroscience·Nan-Jie Xu, Mark Henkemeyer
Feb 13, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Caroline GregorianHong Wu
Jun 6, 2009·Cell Stem Cell·Freda D Miller, Andrée Gauthier-Fisher
Oct 27, 2009·Developmental Cell·Sarah BrisbinIan Chin-Sang
Jan 13, 2010·Cold Spring Harbor Perspectives in Biology·Nikolaos GiagtzoglouHugo J Bellen
Dec 24, 2011·Molecular Neurodegeneration·Yangling Mu, Fred H Gage
Jun 19, 2012·Cell Stem Cell·Luis C FuentealbaArturo Alvarez-Buylla
Sep 18, 2012·Nature Neuroscience·Randolph S AshtonDavid V Schaffer
Nov 3, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Stéphane Rodriguez, Uyen Huynh-Do
May 9, 2014·Science·Katherine G AkersPaul W Frankland
Jun 7, 2014·Annual Review of Neuroscience·Kimberly M ChristianGuo-li Ming
Oct 7, 2014·Nature Cell Biology·Cristina OttoneSimona Parrinello

❮ Previous
Next ❯

Citations

Jul 31, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Yue Li, Weixiang Guo
Jun 28, 2020·Molecular Neurobiology·Tetsade C B PiermartiriCarla Inês Tasca
Jul 28, 2020·Frontiers in Cell and Developmental Biology·Antonela BonafinaFernanda Ledda
Apr 9, 2020·Frontiers in Neurology·Linda OttoboniGianvito Martino
Dec 10, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Nicolas DrayLaure Bally-Cuif
Jun 13, 2019·Stem Cell Reports·Inchul J ChoFiona M Watt
Feb 10, 2021·ACS Applied Materials & Interfaces·Anastasia KorolevaBoris Chichkov
Aug 15, 2021·Translational Neurodegeneration·Miao XuNan-Jie Xu
Aug 28, 2021·Frontiers in Neuroscience·Mihai CeangaSilke Keiner
Nov 5, 2021·Chinese Medical Journal·Jiawei XinXiaodong Pan
Jan 16, 2022·Scientific Reports·Luis Fernando CobarAyumu Tashiro

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
genotyping
Assay
PCR

Software Mentioned

Bioconductor
LAS X
DAVID ( Database for Annotation , Visualization and Integrated...
R
NIH ImageJ
ImageJ
R package limma

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.