PMID: 9549867Apr 29, 1998Paper

A neuronal vacuolar disorder in young rottweiler dogs

The Veterinary Record
T S van den InghJ J van Nes

Abstract

Four rottweiler pups from two litters developed severe progressive signs of spinal ataxia, cerebellar ataxia and tetraparesis/paralysis. The signs started with ataxia of the pelvic limbs at seven to eight weeks of age and progressed to tetraparesis and paralysis within three to five weeks. Postmortem, a vacuolar neuronal disorder was found in the cerebellum, brainstem and the spinal cord, associated with Wallerian type degeneration in the brainstem, cerebellar peduncles and the medullary cord. Electron microscopy revealed empty membrane-bound vacuoles. Immunohistochemistry for PrPSc was negative. The disorder differs clinically and pathologically from other neurological disorders in the breed and a new (familial) neurological disorder in the rottweiler is suspected.

References

May 1, 1984·Veterinary Pathology·D A Gamble, C L Chrisman
Jul 1, 1997·Veterinary Pathology·G D KortzJ F Zachary

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Citations

May 4, 2007·Journal of Feline Medicine and Surgery·Claudia SalvadoriCarlo Cantile
Apr 15, 2011·Journal of Veterinary Internal Medicine·M KleiterM Leschnik
Sep 27, 2003·The Journal of Small Animal Practice·D R Davies, P J Irwin
Sep 20, 2007·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·C SalvadoriC Cantile
Jan 24, 2006·The Veterinary Journal·S SisóM Vandevelde
Aug 2, 2001·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·A N HamirJ Stasko
Dec 24, 2018·Journal of Veterinary Internal Medicine·Quirine E M StassenPeter A J Leegwater
Feb 21, 2008·Veterinary Research·Marion Mathieson SimmonsSusan Carol Tongue
Apr 29, 1998·The Veterinary Record·C J PhillipsS Postlethwaite
Mar 13, 2016·Journal of Veterinary Internal Medicine·T Mhlanga-MutangaduraD P O'Brien

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