A neuropathological study of the disturbance of the nigro-amygdaloid connections in brains from patients with dementia with Lewy bodies

Journal of the Neurological Sciences
Eizo IsekiK Kosaka

Abstract

We neuropathologically and immunohistochemically investigated characteristics of the central amygdaloid nucleus lesion and its relationship with the substantia nigra lesion in dementia with Lewy bodies (DLB) brains. Nine DLB, four Parkinson's disease (PD) and four Alzheimer-type dementia (ATD) cases were examined. The degree of neuronal loss in the substantia nigra was (+)-(+++) in DLB cases, (+++) in PD cases and (+) in ATD cases. All DLB cases showed spongy change and ubiquitin-positive spheroids in the central nucleus. The degree of spongy change was (+)-(+++) in DLB cases, (+) in PD cases and (-)-(+) in ATD cases, which was correlated with the degree of neuronal loss in the substantia nigra in DLB cases. The number of ubiquitin-positive spheroids was parallel to the degree of spongy change. The central nucleus receives dense dopaminergic fibers from the substantia nigra. Many ubiquitin-positive spheroids were also positive to alpha-synuclein and tyrosine-hydroxylase, suggesting that they derive from the degeneration of terminal or distal axons of Lewy body-bearing dopaminergic neurons in the substantia nigra. The disturbance of the dopaminergic connections from the substantia nigra to the central nucleus may be responsible ...Continue Reading

References

Mar 1, 1979·Experimental Neurology·M K SangheraA Roper-Hall
Jun 1, 1978·The American Journal of Psychiatry·C MoskovitzH L Klawans
Jun 1, 1990·Journal of Neurology·K Kosaka
Jun 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·E J ByrneR B Godwin-Austen
Apr 1, 1996·Current Opinion in Neurobiology·M Gallagher, A A Chiba
Dec 1, 1995·Rinshō shinkeigaku = Clinical neurology·K Kosaka
Aug 1, 1997·Journal of the Neurological Sciences·E IsekiK Kosaka

❮ Previous
Next ❯

Citations

Jun 15, 2005·Progress in Retinal and Eye Research·Alan V WhitmoreSimon W M John
Jan 16, 2002·Journal of the Neurological Sciences·Kurt A Jellinger
Jun 22, 2012·Brain : a Journal of Neurology·Yaping ChuJeffrey H Kordower
Jan 31, 2012·Experimental Neurology·Robert E Burke, Karen O'Malley
Jun 28, 2008·Neurotoxicology·Richard M LopachinDavid S Barber
Apr 21, 2006·Journal of the Neurological Sciences·Ryoko YamamotoHeii Arai
Nov 19, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Megan K HerbertMarcel M Verbeek
Jun 19, 2013·Experimental Neurology·Ilse S Pienaar, Wilma van de Berg
Oct 23, 2002·Brain : a Journal of Neurology·Antony J HardingGlenda M Halliday
Apr 8, 2015·Biochemical Society Transactions·Aleksandar RakovicChristine Klein
Mar 20, 2021·Frontiers in Cellular Neuroscience·Nolwazi Z GcwensaLaura A Volpicelli-Daley
May 4, 2002·Science·Martin C RaffJohn T Finn

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Alpha-Synuclein Aggregation (MDS)

Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.