A neuropeptide-centric view of psychostimulant addiction.

British Journal of Pharmacology
Benjamin Boutrel

Abstract

Drugs of abuse all share common properties classically observed in human beings and laboratory animals. They enhance neural firing and dopamine tone within the nucleus accumbens and produce progressively greater drug-induced motor responses defined as behavioural sensitization. They produce conditioned place preference, a behavioural model of incentive motivation, which highlights the role of environmental cues in drug addiction. They increase brain reward function as seen by a lowering of intracranial self-stimulation thresholds. And last but not least, they are self-administered, and sometimes even abused, and can trigger reinstatement of drug-seeking behaviour in animals extinguished from drug self-administration. It has long been considered that the reinforcing properties of virtually all drugs of abuse, more specifically psychostimulants, are primarily dependent on activation of the mesolimbic dopamine system. However, recent evidence raises the importance of dopamine-independent mechanisms in reward-related behaviours. The overwhelming body of evidence that indicates a critical role for the mesolimbic dopamine system in the reinforcing effect of psychostimulants should not mask the key contribution of other modulatory sys...Continue Reading

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Citations

Dec 2, 2009·Brain Research·Benjamin BoutrelLuis de Lecea
Mar 13, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Diana Simmons, David W Self
Apr 29, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Elena CholerisRobert G Welsman
Mar 30, 2017·Expert Opinion on Investigational Drugs·Kirsten C MorleyPaul S Haber
Jul 14, 2009·Neuropharmacology·Rachel J SmithGary Aston-Jones
Feb 21, 2018·The Journal of Trauma and Acute Care Surgery·Jamie E AndersonJoseph M Galante
Jun 16, 2009·Journal of Neuroendocrinology·Alfonso Abizaid
Jun 26, 2018·The International Journal of Neuroscience·Yuan FanJie Bai
May 23, 2014·Frontiers in Systems Neuroscience·Kevin D LominacKaren K Szumlinski
May 29, 2014·British Journal of Pharmacology·B Jupp, J W Dalley
Nov 7, 2017·Toxicology Mechanisms and Methods·Fahimeh MobarakiAlireza Ebrahimzadeh-Bideskan
Apr 15, 2009·Current Opinion in Psychiatry
Apr 25, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity

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