A Neurophysiological Measure of Reward Sensitivity and its Limited Association with Anhedonia in Adolescents and Young Adults

BioRxiv : the Preprint Server for Biology
David W FrankFrancesco Versace

Abstract

Anhedonia (i.e., the attenuated ability to enjoy pleasurable stimuli) characterizes multiple mood disorders, but its neurophysiological underpinnings are not yet clear. Here, we measured event-related potentials in 116 adolescents and young adults engaged in a signal detection task designed to objectively characterize the anhedonic phenotype. In line with previous studies, the behavioral results showed that approximately 35% of the sample did not develop a response bias towards the more frequently rewarded stimuli (a sign of low hedonic capacity). The event-related potentials (ERPs) evoked by the reward feedback stimuli delivered during the task showed that individuals that did not develop a response bias had significantly less cortical positivity at Fz from 224 ms to 316 ms post feedback onset compared to those that developed a response bias during the task. However, further analyses showed that this between groups difference was relatively weak, as it disappeared when we controlled for response-locked ERPs. Furthermore, the response bias observed in the signal detection task was not strongly associated with self-reported ratings of hedonic capacity. We conclude that even though the signal detection task may be used as a rewar...Continue Reading

Related Concepts

Cerebral Cortex
Anhedonia
Potentials, Event-Related
Mood Disorders
Analysis
Population Group
Neurological System Process
Detection
Study

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