A neutral lipid-enriched diet improves myelination and alleviates peripheral nerve pathology in neuropathic mice

Experimental Neurology
Ye ZhouLucia Notterpek

Abstract

Charcot-Marie-Tooth (CMT) diseases comprise a genetically heterogeneous group of hereditary peripheral neuropathies. Trembler J (TrJ) mice carry a spontaneous mutation in peripheral myelin protein 22 (PMP22) and model early-onset, severe CMT type 1E disease. Recent studies indicate that phospholipid substitution, or cholesterol-enriched diet, benefit myelinated nerves, however such interventions have not been tested in early-onset dysmyelinating neuropathies. Here, we examined the lipid profile of peripheral nerves from 6-month-old TrJ mice with advanced neuropathy and tested the impact of a 6-week-long neutral lipid-enriched high-fat diet (HFD) on neuropathy progression in young, newly-weaned mice. Oil Red O staining showed pronounced neutral lipid accumulation in nerves from 6-month-old TrJ mice, along with elevated levels of key cholesterol and triglyceride transport proteins including apoE, LRP1 and ABCA1, compared with wild type (Wt). In young mice, the short-term HFD intervention increased serum cholesterol levels without impacting triglycerides, or body and liver weights. Tissue samples from neuropathic TrJ mice showed improvements in the maintenance of myelinated axons after the 6-week-long dietary intervention, and thi...Continue Reading

References

Dec 1, 1979·Neuroscience Letters·S Larrouquère-RégnierJ M Bourre
May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·U SuterE M Shooter
Mar 19, 1992·Nature·U SuterE M Shooter
Nov 1, 1991·Journal of Neuropathology and Experimental Neurology·T W BouldinN D Goines
Feb 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M J IgnatiusE M Shooter
Mar 1, 1996·Journal of Neuroscience Research·M E ShyS S Scherer
Jan 1, 1997·Muscle & Nerve·V V IonasescuR Koenigsberger
Feb 1, 2000·Journal of Cellular Physiology·T Scholzen, J Gerdes
Oct 1, 1959·Journal of Neurochemistry·C W ADAMS, A N DAVISON
Jun 1, 1965·Journal of the American Oil Chemists' Society·J F BERRYR R WADE
Oct 3, 2003·Genes & Development·Mark H G VerheijenGreg Lemke
Mar 29, 2005·Nature Neuroscience·Gesine SaherKlaus-Armin Nave
Mar 31, 2005·Molecular and Cellular Neurosciences·Tiziana VigoAngelo Schenone
Jan 27, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stephanie A AmiciLucia Notterpek
Oct 27, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·W Marie CampanaSteven L Gonias
Jul 27, 2007·The Journal of Biological Chemistry·Maria PertusaHugo Cabedo
May 15, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gesine SaherKlaus-Armin Nave
Feb 23, 2010·Biochimica Et Biophysica Acta·Jean E Vance, Hideki Hayashi
Jun 19, 2012·Nature Medicine·Gesine SaherKlaus-Armin Nave
Dec 12, 2012·Molecular Neurobiology·Jun LiJiasong Guo
Dec 18, 2012·Journal of Neurology, Neurosurgery, and Psychiatry·Takashi Kanda
Jan 23, 2013·Journal of Neuroscience Research·Jan SedzikKazuhiro Ikenaka
Nov 19, 2014·International Journal of Endocrinology·Lingling XuYaoming Xue
Nov 28, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sooyeon LeeLucia Notterpek
Nov 29, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·V FridmanUNKNOWN Inherited Neuropathies Consortium

❮ Previous
Next ❯

Citations

Apr 2, 2020·Cells·Yannick PoitelonSophie Belin
Jun 10, 2020·Proceedings of the National Academy of Sciences of the United States of America·Justin T MarinkoCharles R Sanders
Aug 28, 2021·International Journal of Molecular Sciences·Antonietta BernardoAntonella Ferrante
Aug 27, 2021·Membranes·Miliça RistovskiJyh-Yeuan Lee
Sep 26, 2021·International Journal of Pharmaceutics·Marie CaillaudLiliane Massaad-Massade

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.