A neutralizing anti-fibroblast growth factor (FGF) 8 monoclonal antibody shows anti-tumor activity against FGF8b-expressing LNCaP xenografts in androgen-dependent and -independent conditions

The Prostate
Kumiko Maruyama-TakahashiKenya Shitara

Abstract

Fibroblast growth factor 8-isoform b (FGF8b) has been detected in human clinical sex-organ related cancers including hormone-refractory prostate cancer. There are, however, few relevant experimental models. A murine monoclonal anti-FGF8 antibody, KM1334, has been shown to neutralize FGF8b and inhibit the growth of androgen-dependent mouse mammary SC-3 cells in vitro and in vivo. In the present study, we evaluated the anti-tumor activity of KM1334 against androgen-dependent and -independent progression of FGF8b-expressing human prostate cancer xenografts. FGF8b cDNA was transfected into androgen-dependent human prostate cancer cell line LNCaP, and its xenograft tumors were established subcutaneously in SCID mice with or without castration. KM1334 at the dose of 400 microg/head was injected twice weekly. FGF8b-expressing LNCaP cells secreted FGF8b, showed enhanced level of Erk1/2 phosphorylation, and showed more potent growth properties than mock-expressing cells in vitro and in vivo. KM1334 reduced these properties in vitro, inhibited tumorigenecity in vivo (T/C=0.33), and showed anti-tumor activity against established tumors (T/C=0.47) of FGF8b-expressing cells. FGF8b-expressing LNCaP tumors were androgen-dependent. However, th...Continue Reading

References

Oct 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·A TanakaK Matsumoto
Jul 1, 1996·Genomics·J GemelC A MacArthur
Jan 15, 1998·Progress in Nucleic Acid Research and Molecular Biology·W L McKeehanM Kan
Sep 29, 1998·International Review of Cytology·G Szebenyi, J F Fallon
May 1, 1999·Biochemical and Biophysical Research Communications·M YamasakiN Itoh
Nov 1, 2000·Cell·J Schlessinger
Nov 10, 2000·International Journal of Cancer. Journal International Du Cancer·E ValveP Härkönen
Jun 15, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·E M ValveP L Härkönen
Oct 26, 2002·Brain Research. Molecular Brain Research·Masamitsu HoshikawaNobuyuki Itoh
Oct 31, 2002·Virchows Archiv : an International Journal of Pathology·Akira TanakaKen Saito
Jan 2, 2003·Nature Reviews. Drug Discovery·Ole Henrik Brekke, Inger Sandlie
Jun 5, 2003·British Journal of Cancer·V J GnanapragasamH Y Leung
Apr 15, 2004·Endocrine Reviews·Cynthia A Heinlein, Chawnshang Chang
Sep 25, 2004·The Prostate·Hiroshi MiyamotoChawnshang Chang
May 18, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Naoki ShimadaKenya Shitara
Feb 21, 2006·Cancer Research·Chen ZhongPradip Roy-Burman

❮ Previous
Next ❯

Citations

Aug 1, 2013·Apoptosis : an International Journal on Programmed Cell Death·Kai Hung TiongChee-Onn Leong
Feb 28, 2009·Nature Reviews. Drug Discovery·Andrew Beenken, Moosa Mohammadi
Dec 12, 2012·International Journal of Nanomedicine·Anna SzlachcicJacek Otlewski
Nov 23, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R DienstmannJ Tabernero
Jan 16, 2016·Seminars in Cell & Developmental Biology·Xiaokun LiFen Wang
Sep 16, 2015·Seminars in Cell & Developmental Biology·Jun Zhang, Yang Li
Jun 30, 2011·The Biochemical Journal·Jørgen WescheEllen Margrethe Haugsten
Mar 28, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Wen-Jun XiaoDing-Wei Ye
Sep 8, 2010·Nature Reviews. Urology·Maria KarlouEleni Efstathiou
Jun 26, 2018·Expert Review of Anticancer Therapy·Gaia Cristina GhediniArianna Giacomini
Jul 31, 2020·Physiological Reviews·Arianna GiacominiMarco Presta
Jun 1, 2017·Molecular Medicine Reports·Xiaomian LinXiaoping Wu
Jun 29, 2018·International Journal of Molecular Sciences·Qi HuiXiaojie Wang
Dec 9, 2020·Journal of Experimental & Clinical Cancer Research : CR·Anna Di MatteoClaudia Ghigna
Nov 5, 2010·Molecular Cancer Research : MCR·Ellen Margrethe HaugstenJørgen Wesche
Sep 21, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Paul G CornNora Navone
Jul 19, 2011·Molecular Cancer Therapeutics·Daria LealiMarco Presta
Mar 1, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R DienstmannJ Tabernero
Apr 25, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.