Abstract
Fibroblast growth factor 8-isoform b (FGF8b) has been detected in human clinical sex-organ related cancers including hormone-refractory prostate cancer. There are, however, few relevant experimental models. A murine monoclonal anti-FGF8 antibody, KM1334, has been shown to neutralize FGF8b and inhibit the growth of androgen-dependent mouse mammary SC-3 cells in vitro and in vivo. In the present study, we evaluated the anti-tumor activity of KM1334 against androgen-dependent and -independent progression of FGF8b-expressing human prostate cancer xenografts. FGF8b cDNA was transfected into androgen-dependent human prostate cancer cell line LNCaP, and its xenograft tumors were established subcutaneously in SCID mice with or without castration. KM1334 at the dose of 400 microg/head was injected twice weekly. FGF8b-expressing LNCaP cells secreted FGF8b, showed enhanced level of Erk1/2 phosphorylation, and showed more potent growth properties than mock-expressing cells in vitro and in vivo. KM1334 reduced these properties in vitro, inhibited tumorigenecity in vivo (T/C=0.33), and showed anti-tumor activity against established tumors (T/C=0.47) of FGF8b-expressing cells. FGF8b-expressing LNCaP tumors were androgen-dependent. However, th...Continue Reading
References
Aug 7, 1975·Nature·G Köhler, C Milstein
Oct 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·A TanakaK Matsumoto
Dec 14, 1990·Biochemical and Biophysical Research Communications·J VeldscholteE Mulder
Apr 24, 1995·FEBS Letters·A TanakaH Yoshida
Nov 1, 1995·Genomics·R A WhiteC A MacArthur
Jul 1, 1996·Genomics·J GemelC A MacArthur
Jan 15, 1998·Progress in Nucleic Acid Research and Molecular Biology·W L McKeehanM Kan
Apr 3, 1998·Oncogene·N Rudra-GangulyP Roy-Burman
May 16, 1998·Oncogene·Q C LauR Müller
Sep 29, 1998·International Review of Cytology·G Szebenyi, J F Fallon
Dec 5, 1998·Oncogene·D Daphna-IkenC A MacArthur
Feb 19, 1999·Oncogene·S K MarshC L Johnston
Apr 2, 1999·The European Journal of Neuroscience·A J LiT Imamura
May 1, 1999·Biochemical and Biophysical Research Communications·M YamasakiN Itoh
May 29, 1999·Oncogene·T J DorkinH Y Leung
Nov 1, 2000·Cell·J Schlessinger
Nov 10, 2000·International Journal of Cancer. Journal International Du Cancer·E ValveP Härkönen
Jun 12, 2001·Molecular Immunology·K NakamuraN Hanai
Jun 15, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·E M ValveP L Härkönen
Jun 23, 2001·Oncogene·M M MattilaP L Härkönen
Oct 26, 2002·Brain Research. Molecular Brain Research·Masamitsu HoshikawaNobuyuki Itoh
Oct 31, 2002·Virchows Archiv : an International Journal of Pathology·Akira TanakaKen Saito
Jan 2, 2003·Nature Reviews. Drug Discovery·Ole Henrik Brekke, Inger Sandlie
Jun 5, 2003·British Journal of Cancer·V J GnanapragasamH Y Leung
Oct 18, 2003·Gene·P J Marie
Apr 15, 2004·Endocrine Reviews·Cynthia A Heinlein, Chawnshang Chang
Aug 26, 2004·Advances in Cancer Research·Paul W Finch, Jeffrey S Rubin
Sep 25, 2004·The Prostate·Hiroshi MiyamotoChawnshang Chang
May 18, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Naoki ShimadaKenya Shitara
Feb 21, 2006·Cancer Research·Chen ZhongPradip Roy-Burman
Jan 16, 2007·The Prostate·Gui-Min WangDavid Moscatelli
Citations
Aug 1, 2013·Apoptosis : an International Journal on Programmed Cell Death·Kai Hung TiongChee-Onn Leong
Feb 28, 2009·Nature Reviews. Drug Discovery·Andrew Beenken, Moosa Mohammadi
Dec 12, 2012·International Journal of Nanomedicine·Anna SzlachcicJacek Otlewski
Nov 23, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R DienstmannJ Tabernero
Feb 3, 2009·Urology·Matthew N Simmons, Eric A Klein
Mar 27, 2012·Expert Opinion on Therapeutic Targets·Simona CeccarelliCinzia Marchese
Jan 16, 2016·Seminars in Cell & Developmental Biology·Xiaokun LiFen Wang
Feb 21, 2013·The Journal of Pathology·Roberto RoncaMarco Presta
Nov 19, 2011·The Prostate·Hirotoshi KawataAkira Tanaka
Sep 16, 2015·Seminars in Cell & Developmental Biology·Jun Zhang, Yang Li
Jun 30, 2011·The Biochemical Journal·Jørgen WescheEllen Margrethe Haugsten
Mar 28, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Wen-Jun XiaoDing-Wei Ye
Sep 8, 2010·Nature Reviews. Urology·Maria KarlouEleni Efstathiou
Jun 26, 2018·Expert Review of Anticancer Therapy·Gaia Cristina GhediniArianna Giacomini
Dec 29, 2016·Oncotarget·Young Kwang ChaeFrancis J Giles
Nov 16, 2017·Oncotarget·Roberto RoncaDomenico Ribatti
Nov 3, 2017·Molecular Oncology·Karin SchelchGlen Reid
Jul 31, 2020·Physiological Reviews·Arianna GiacominiMarco Presta
Jun 1, 2017·Molecular Medicine Reports·Xiaomian LinXiaoping Wu
Apr 29, 2015·Oncotarget·Arianna GiacominiRoberto Ronca
Jun 29, 2018·International Journal of Molecular Sciences·Qi HuiXiaojie Wang
Dec 5, 2014·Oncotarget·Rui LiuCanhua Huang
Oct 4, 2020·Prostate Cancer and Prostatic Diseases·Naomi B HaasErica L Carpenter
Dec 9, 2020·Journal of Experimental & Clinical Cancer Research : CR·Anna Di MatteoClaudia Ghigna
Nov 5, 2010·Molecular Cancer Research : MCR·Ellen Margrethe HaugstenJørgen Wesche
Sep 21, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Paul G CornNora Navone
Jul 19, 2011·Molecular Cancer Therapeutics·Daria LealiMarco Presta
Mar 1, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R DienstmannJ Tabernero
Apr 25, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity