A new [2 + 1] mixed ligand concept based on [99(m)Tc(OH2)3(CO)3]+: a basic study

Dalton Transactions : an International Journal of Inorganic Chemistry
Stefan MundwilerRoger Alberto

Abstract

Mixed ligand fac-tricarbonyl complexes of the general formula [M(L1)(L2)(CO)3](M = Re, 99(m)Tc, L1= imidazole, benzyl isocyanide, L2 = 1H-imidazole-4-carboxylic acid, pyridine-2,4-dicarboxylic acid, pyridine-2,5-dicarboxylic acid) have been prepared starting from the precursors [M(OH2)3(CO)3]+. The complexes can be obtained in good yield and purity in a two-step procedure by first attaching the bidentate ligand followed by addition of the monodentate. 99mTc compounds can also be prepared at the tracer level in one-pot procedures with L1 and L2 being concomitantly present. This [2 + 1] approach allows the labeling of bioactive molecules containing a monodentate or a bidentate donor site. Examples given in here are N-(tert-butoxycarbonyl)glycyl-N-(3-(imidazol-1-yl)propyl)phenylalaninamide, 5-((3-(imidazol-1-yl)propyl)aminomethyl)-2'-deoxyuridine and 4-(5-isonitrilpentyl)-1-(2-methoxyphenyl)-piperazine as L1 and N-((6-carboxypyridine-3-yl)methyl)glycylphenylalanine as L2. The corresponding second ligand can be used to influence the physico-chemical properties of the conjugate. The crystal structures of [99Tc(OH2)(imc)(CO)3], [Re(OH2)(2,4-dipic)(CO)3], [Re(bic)(2,4-dipic)(CO)3] and [Re(im)(2,5-dipic)(CO)3] are reported.

References

Dec 1, 1984·Journal of Medicinal Chemistry·A SrinivasanY C Cheng
Sep 6, 2000·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·S SeifertB Johannsen
Nov 17, 2001·Seminars in Nuclear Medicine·S BanerjeeN Ramamoorthy
Dec 26, 2001·Chemical Reviews·S S Jurisson, J D Lydon
Dec 26, 2001·Chemical Reviews·S Liu, D S Edwards

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Citations

Jan 1, 2008·Acta Crystallographica. Section E, Structure Reports Online·Marietjie Schutte, Hendrik G Visser
Jan 1, 2008·Acta Crystallographica. Section E, Structure Reports Online·Marietjie SchutteAndreas Roodt
Jan 1, 2009·Acta Crystallographica. Section E, Structure Reports Online·Janine SuthiramAndreas Roodt
Jan 1, 2009·Acta Crystallographica. Section E, Structure Reports Online·Marietjie SchutteAlice Brink
Jan 1, 2010·Acta Crystallographica. Section E, Structure Reports Online·Marietjie SchutteAndreas Roodt
Jan 1, 2010·Acta Crystallographica. Section E, Structure Reports Online·Janine SuthiramAndreas Roodt
Jan 1, 2010·Acta Crystallographica. Section E, Structure Reports Online·Alice BrinkAndreas Roodt
Jan 1, 2010·Acta Crystallographica. Section E, Structure Reports Online·Alice BrinkAndreas Roodt
Jan 6, 2012·Acta Crystallographica. Section E, Structure Reports Online·Hendrik G VisserGerdus Kemp
Feb 15, 2011·Nuclear Medicine and Biology·Mariella Adriana TeránEduardo Savio
Sep 22, 2009·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·L FuksJ Narbutt
Aug 6, 2008·Nuclear Medicine and Biology·Marie-Laure BiechlinAmaury du Moulinet d'Hardemare
Nov 1, 2006·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Xianzhong ZhangXuebin Wang
Dec 7, 2010·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Przemysław KoźmińskiSylwia Kowalska
Jan 31, 2015·Inorganic Chemistry·Abdolreza YazdaniJohn F Valliant
Jun 29, 2017·Inorganic Chemistry·Antonio SheganiMinas S Papadopoulos
Dec 18, 2013·Journal of Labelled Compounds & Radiopharmaceuticals·Beverley L EllisHarbans L Sharma
Oct 23, 2008·Dalton Transactions : an International Journal of Inorganic Chemistry·Lukas KromerRoger Alberto
Feb 12, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·Adam L MoorePaul D Benny
Oct 16, 2008·Magnetic Resonance in Chemistry : MRC·Michael Bühl, Volodymyr Golubnychiy
Dec 12, 2013·Journal of Labelled Compounds & Radiopharmaceuticals·Timothy U ConnellPaul S Donnelly
Jan 4, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·Thomas R HayesPaul D Benny
Oct 11, 2019·Contrast Media & Molecular Imaging·Ningning SongJinhua Zhao
Mar 24, 2016·Acta Crystallographica. Section E, Crystallographic Communications·Charalampos TriantisMinas Papadopoulos
Jun 16, 2017·Journal of Labelled Compounds & Radiopharmaceuticals·Dionysia Papagiannopoulou
Jun 28, 2018·Inorganic Chemistry·Charalampos TriantisMinas S Papadopoulos
Oct 24, 2012·Inorganic Chemistry·Marietjie SchutteHendrik G Visser
Oct 19, 2021·Inorganic Chemistry·Maximilian Roca Jungfer, Ulrich Abram

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