A new acylated flavonol from the aerial parts of Asteriscus maritimus (L.) Less (Asteraceae)

Natural Product Research
Marwa I EzzatSayed A El-Toumy

Abstract

Phytochemical investigation of the flowering aerial parts of Asteriscus maritimus (L.) Less (Asteraceae) led to the isolation of a new compound: patuletin 7-O-β-D-[(2″'S) 6″(3″'-hydroxy-2″'-methyl-propanoyl)] glucopyranoside, together with five known metabolites; β-sitosterol 2, chlorogenic acid 3, P-hydroxy -methylbenzoate 4, luteolin 5 and protocatechuic acid 6. The structures of the isolated compounds were determined by comprehensive analyses of its 1D and 2D NMR, HRMS and compared with previously known analogues. The ethanolic extract of the flowering aerial parts of A. maritimus was found to be safe (LD50 = 4.6 mg/kg) and possess significant antioxidant and anti-inflammatory activities and this was in accordance with its high phenolic content (107.36 ± 0.051 mg GAE/g extract).

References

May 1, 1969·Life Sciences·S G Eliasson, J M Samet
Feb 24, 2001·Phytochemistry·A P RauterA S Feliciano
Dec 10, 2002·Current Cancer Drug Targets·David J NewmanEdward A Sausville
Dec 1, 1962·Proceedings of the Society for Experimental Biology and Medicine·C A WINTERG W NUSS
Nov 18, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·V RajkumarR Ashok Kumar

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Citations

Sep 24, 2019·Natural Product Research·Hanane AchoubSamir Benayache

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Methods Mentioned

BETA
circular dichroism
column chromatography
NMR

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