A new age-related cutoff of medial temporal atrophy scale on MRI improving the diagnostic accuracy of neurodegeneration due to Alzheimer's disease in a Chinese population

BMC Geriatrics
Mingqing WeiJinzhou Tian

Abstract

Visual rating scales are still the most popular tools in assessing atrophy degrees of whole brain and lobes. However, the false negative rate of the previous cutoff score of visual rating scales was relatively high for detecting dementia of Alzheimer's type (DAT). This study aimed to evaluate the diagnostic value of new cutoffs of visual rating scales on magnetic resonance imaging for discriminating DAT in a Chinese population. Out of 585 enrolled subjects, 296 participants were included and diagnosed as normal cognition (NC)(n = 87), 138 diagnosed as amnestic mild cognitive impairment (aMCI), and 71 as dementia of Alzheimer's type (DAT). Receiver operating characteristic (ROC) curve analyses were used to calculate the diagnostic value of visual rating sales (including medial temporal atrophy (MTA), posterior atrophy rating scale (PA),global cortical atrophy scale (GCA) and medial temporal-lobe atrophy index (MTAi))for detecting NC from DAT . Scores of MTA correlated to age and Mini-mental state examination score. When used to detect DAT from NC, the MTA showed highest diagnostic value than other scales, and when the cutoff score of 1.5 of MTA scale, it obtained an optimal sensitivity (84.5%) and specificity (79.1%) respectivel...Continue Reading

References

Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Sep 19, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·A T DuM W Weiner
Dec 26, 2001·Archives of Neurology·R C PetersenB Winblad
Apr 15, 2005·The New England Journal of Medicine·Ronald C PetersenUNKNOWN Alzheimer's Disease Cooperative Study Group
Apr 26, 2005·Aging Clinical and Experimental Research·Lorena BrescianiGiovanni B Frisoni
Jan 13, 2006·Neurobiology of Aging·Josephine BarnesNick C Fox
Jun 21, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Yi LiMony J de Leon
Mar 9, 2011·International Journal of Geriatric Psychiatry·Lorena RamiJose Luis Molinuevo
Aug 2, 2011·European Radiology·Esther L G E KoedamMike P Wattjes
Apr 10, 2014·Frontiers in Aging Neuroscience·Manuel Menéndez-GonzálezOscar Arias-Carrión
Mar 11, 2015·Journal of Internal Medicine·D FerreiraUNKNOWN AddNeuroMed consortium and the Alzheimer's Disease Neuroimaging Initiative
Nov 15, 2017·Journal of the American Geriatrics Society·Mingqing WeiJinzhou Tian

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Citations

Nov 13, 2018·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Betul Z YalcinerDevrim Unay

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Methods Mentioned

BETA
Imaging

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