A New Agonist for Peroxisome Proliferation-activated Receptor γ (PPARγ), Fraglide-1 from Zhenjiang Fragrant Vinegar: Screening and Characterization Based on Cell Culture Experiments

Journal of Oleo Science
Yoshio Tsujino

Abstract

Zhenjiang fragrant vinegar (Kozu) is a black rice vinegar that has been used as a traditional Chinese medicine and has various health benefits, including anti-obesity effects. In the present study, using luciferase reporter assays of PPARγ promoter activity, a novel ingredient from 8-year-old Kozu, 5-hydroxy-4-phenyl-butenolide, was isolated. The newly found agonist was named as "Fraglide-1". Moreover, in subsequent experiments, it was confirmed that fraglide-1 was an PPARγ agonist and it could increase expression level of the uncoupling protein (UCP)-1. Fraglide-1 was chemically synthesized and it was verified that expression of the PPARγ was increased in dose dependent manner. Although Kozu has been consumed globally as a functional food for thousands of years, the mechanisms behind its health effects have not been characterized. The active ingredient of Kozu was successfully found and the results unraveled a longtime mystery about Kozu for its beneficial health effect.

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Citations

Jun 29, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yosuke TabeiYoshihiro Nakajima
Dec 12, 2019·Expert Opinion on Therapeutic Patents·Ichiro Takada, Makoto Makishima
Feb 8, 2020·Journal of Cellular and Molecular Medicine·Liwei WuJianye Wu
Nov 14, 2017·Journal of Oleo Science·Aydan H YatmazNaohiro Gotoh

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