PMID: 45864Jan 27, 1975

A new antigen-antibody system. Clinical significance in long-term carriers of hepatitis B surface antigen

JAMA : the Journal of the American Medical Association
L O MagniusS Iwarson


A new antigen-antibody system was recently described in hepatitis B surface antigen (HBSAG(-positive sera. Despite indications of heterogeneity in specificity, the designations "e antigen" and "e antibodies" are used for the system as such in this articly. E'IGHT OF 17 long-term carriers of HBSAg with a histological picture of chronic persistent hepatitis or chronic aggressive hepatitis carried the e antigen, while none had demonstrable e antibodies in serum. Ten of 12 healthy carriers with e antibodies were blood donors who had donated 95 units of blood; none of these carriers was associeated with a reported case of posttransfusion hepatitis. In five individuals in the incubation stage of hepatitis B, e antigen appeared simultaneously with HBSAg but before the rise in transaminase levels. This finding further links e antigen to hepatitis B.


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Related Concepts

Hepatitis B Antigens
Antigenic Specificity
Alkaline Phosphatase
Acute Disease
Immune complex
Antigens, Viral
Carrier of Disorder

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