A new approach for evaluating antigen-specific T cell responses to myelin antigens during the course of multiple sclerosis

Journal of Neuroimmunology
Nathalie ArbourMichael B A Oldstone

Abstract

We used a flow cytometry assay to measure proliferation and cytokine production of self-antigen-specific T cells in individual patients during the clinical course of multiple sclerosis (MS). Myelin-associated oligodendrocytic basic protein (MOBP) was selected for proof of principles in the assay, along with myelin basic protein (MBP) to assess specific activated T cells in 10 MS patients over an 18-month period, in parallel with brain magnetic resonance imaging (MRI) scans and clinical rating scale. A positive correlation occurred between antigen-specific T cell proliferation and interferon-gamma production with clinical relapses and MRI lesion activity that was absent when the same patients were in remission.

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Citations

Jul 4, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Samantha JilekRenaud A Du Pasquier
Mar 18, 2005·Annual Review of Immunology·Mireia Sospedra, Roland Martin
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Feb 23, 2019·Frontiers in Immunology·Laurine LegrouxNathalie Arbour
Jun 29, 2017·Clinical Rheumatology·Talita Siara Almeida BaptistaMoisés Evandro Bauer
Mar 18, 2021·Clinical & Translational Immunology·Marie-Laure ClénetNathalie Arbour
May 11, 2021·Frontiers in Immunology·Florent LemaîtreNathalie Arbour

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