A new approach for evaluating antigen-specific T cell responses to myelin antigens during the course of multiple sclerosis

Journal of Neuroimmunology
Nathalie ArbourMichael B A Oldstone


We used a flow cytometry assay to measure proliferation and cytokine production of self-antigen-specific T cells in individual patients during the clinical course of multiple sclerosis (MS). Myelin-associated oligodendrocytic basic protein (MOBP) was selected for proof of principles in the assay, along with myelin basic protein (MBP) to assess specific activated T cells in 10 MS patients over an 18-month period, in parallel with brain magnetic resonance imaging (MRI) scans and clinical rating scale. A positive correlation occurred between antigen-specific T cell proliferation and interferon-gamma production with clinical relapses and MRI lesion activity that was absent when the same patients were in remission.


Apr 1, 1992·The Journal of Experimental Medicine·K W WucherpfennigD A Hafler
Mar 1, 1991·The Journal of Clinical Investigation·K SelmajC F Brosnan
Apr 1, 1986·Annals of Neurology·J BurnsD Pleasure
Aug 1, 1989·The Journal of Experimental Medicine·F M HofmanJ E Merrill
Apr 1, 1988·Annals of Neurology·K W Selmaj, C S Raine
Apr 1, 1995·Annals of Neurology·B Cannella, C S Raine
Jan 1, 1994·Annals of Neurology·H S Panitch
Feb 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·M K Sharief, E J Thompson
Sep 1, 1997·Nature Medicine·Marc S HorwitzMichael B A Oldstone
Jun 18, 1998·Journal of Neuroimmunology·P A CalabresiH F McFarland
Sep 3, 1998·Journal of Neuroimmunology·P A CalabresiE P Cowan
Jan 20, 1999·Proceedings of the Association of American Physicians·J S RomineE Beutler
Sep 28, 2000·The New England Journal of Medicine·J H NoseworthyB G Weinshenker
Feb 15, 2001·Journal of Neuroscience Research·N HellingsP Stinissen
Jul 27, 2001·Journal of Immunological Methods·H T MaeckerL J Picker
Dec 18, 2001·Journal of Neuroscience Research·M VergelliL Massacesi

❮ Previous
Next ❯


Jul 4, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Samantha JilekRenaud A Du Pasquier
Mar 18, 2005·Annual Review of Immunology·Mireia Sospedra, Roland Martin
Aug 26, 2014·PloS One·Simone C WuestBibiana Bielekova
Aug 2, 2014·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Benjamin M Segal
Jul 26, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Chris J HedegaardClaus H Nielsen
Jan 24, 2007·Immunology·Marina ZafranskayaMatthias Eberl
Jul 26, 2014·Annual Review of Psychology·Robert KurzbanStuart A West
Oct 16, 2019·The Journal of Experimental Medicine·Catriona A WagnerJoan M Goverman
Sep 14, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Raphael SchneiderNathalie Arbour
Feb 23, 2019·Frontiers in Immunology·Laurine LegrouxNathalie Arbour
Jun 29, 2017·Clinical Rheumatology·Talita Siara Almeida BaptistaMoisés Evandro Bauer
Mar 18, 2021·Clinical & Translational Immunology·Marie-Laure ClénetNathalie Arbour
May 11, 2021·Frontiers in Immunology·Florent LemaîtreNathalie Arbour

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists
Sungpil HanBibiana Bielekova
Rheumatic Diseases Clinics of North America
John C HallAntony Rosen
Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
P Di PedeP Sansoni
© 2022 Meta ULC. All rights reserved