A new approach for modeling patient overall radiosensitivity and predicting multiple toxicity endpoints for breast cancer patients

Acta Oncologica
Chamberlain MbahLiv Veldeman

Abstract

Evaluation of patient characteristics inducing toxicity in breast radiotherapy, using simultaneous modeling of multiple endpoints. In 269 early-stage breast cancer patients treated with whole-breast irradiation (WBI) after breast-conserving surgery, toxicity was scored, based on five dichotomized endpoints. Five logistic regression models were fitted, one for each endpoint and the effect sizes of all variables were estimated using maximum likelihood (MLE). The MLEs are improved with James-Stein estimates (JSEs). The method combines all the MLEs, obtained for the same variable but from different endpoints. Misclassification errors were computed using MLE- and JSE-based prediction models. For associations, p-values from the sum of squares of MLEs were compared with p-values from the Standardized Total Average Toxicity (STAT) Score. With JSEs, 19 highest ranked variables were predictive of the five different endpoints. Important variables increasing radiation-induced toxicity were chemotherapy, age, SATB2 rs2881208 SNP and nodal irradiation. Treatment position (prone position) was most protective and ranked eighth. Overall, the misclassification errors were 45% and 34% for the MLE- and JSE-based models, respectively. p-Values from...Continue Reading

References

Jul 1, 1991·International Journal of Radiation Oncology, Biology, Physics·J R GrayJ Yahalom
Apr 1, 1995·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Feb 15, 1995·International Journal of Radiation Oncology, Biology, Physics·M E TaylorC Rush
Dec 1, 1996·International Journal of Radiation Oncology, Biology, Physics·I TuressonA Odén
Dec 4, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Christian Nicolaj AndreassenJens Overgaard
Dec 14, 2006·The Journal of Clinical Endocrinology and Metabolism·Thomas SkurkHans Hauner
Jan 16, 2007·Breast Cancer Research and Treatment·Carmen LillaJenny Chang-Claude
Feb 27, 2007·The Breast Journal·Maria J CardosoManuel C Oliveira
Mar 31, 2007·Seminars in Radiation Oncology·Michael T MilanoPaul Okunieff
Apr 11, 2007·Artificial Intelligence in Medicine·Jaime S Cardoso, Maria J Cardoso
Oct 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David AzriaBarry S Rosenstein
Feb 8, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Christy GoldsmithUNKNOWN FAST Trialists' Group
Feb 25, 2011·International Journal of Radiation Oncology, Biology, Physics·Gillian C BarnettCharlotte E Coles
May 25, 2011·International Journal of Radiation Oncology, Biology, Physics·Gillian C BarnettSøren M Bentzen
May 31, 2011·Cancer Prevention Research·Patrick G MorrisAndrew J Dannenberg
Jun 8, 2011·Clinical Oncology : a Journal of the Royal College of Radiologists·G C BarnettC E Coles
Oct 18, 2011·Breast Cancer Research and Treatment·Xuezheng SunMelissa A Troester
Feb 4, 2012·Nature Reviews. Drug Discovery·Lorenzo GalluzziGuido Kroemer
Sep 18, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mukesh B MukeshCharlotte E Coles
May 3, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Gillian C BarnettCatharine M L West
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Dec 17, 2014·The Lancet Oncology·Harry BartelinkUNKNOWN European Organisation for Research and Treatment of Cancer Radiation Oncology and Breast Cancer Groups
Dec 20, 2014·Future Oncology·Sarah L KernsBarry S Rosenstein
Jun 15, 2015·International Journal of Radiation Oncology, Biology, Physics·Petra SeiboldJenny Chang-Claude
Sep 30, 2015·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Ursula Hille-BetzChristoph Henkenberens
May 23, 2016·International Journal of Radiation Oncology, Biology, Physics·Liv VeldemanWilfried De Neve

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Citations

Apr 15, 2020·Acta Oncologica·Hans Van HulleLiv Veldeman
Nov 25, 2020·Radiation Oncology Journal·Cecil M Benitez, Susan J Knox

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